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| | Dodeca-2(E),4(E)-dienoic acid isobutylamide(p) Basic information |
| Product Name: | Dodeca-2(E),4(E)-dienoic acid isobutylamide(p) | | Synonyms: | (2E,4E)-N-isobutyldodeca-2,4-dienamide;2,4-Dodecadienamide, N-(2-methylpropyl)-, (2E,4E)-;Dienamide A2;DODECA-2(E)-DIENOIC ACID ISOBUTYLAMIDE;Dodeca-2(E),4(E)-dienoic acid isobutlamide;2,4-Dodecadienoic acid isobutylamide;Dodeca-2(E),4(E)-dienoic acid isobutylamide(p) | | CAS: | 24738-51-0 | | MF: | C16H29NO | | MW: | 251.41 | | EINECS: | | | Product Categories: | | | Mol File: | 24738-51-0.mol |  |
| | Dodeca-2(E),4(E)-dienoic acid isobutylamide(p) Chemical Properties |
| Melting point | 74-75 °C | | Boiling point | 396.896±15.00 °C(Press: 760.00 Torr)(predicted) | | density | 0.878±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 25 mg/ml) on in Ethanol (up to 25 mg/ml) | | pka | 14.716±0.46(predicted) | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. | | LogP | 4.962 (est) |
| | Dodeca-2(E),4(E)-dienoic acid isobutylamide(p) Usage And Synthesis |
| Description | Dienamide A2 (24738-51-0) is an analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFα mRNA expression in human monocytes/macrophages via the CB2 receptor.1Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively)2. It elevates intracellular Ca2+ levels in CB2-positive but not in CB2-negative cells and this effect was blocked by SR144528.2It significantly inhibits LPS-induced TNFα and IL-1β expression in a CB2-independent manner.2 | | Uses | Kalecide is a natural pesticide of Echinacea angustifolia, Echinacea atrorubens and Piper sarmentosum. | | Definition | ChEBI: (2E,4E)-N-isobutyl-2,4-dodecadienamide is a fatty amide. It has a role as a metabolite. | | References | [1] JUERG GERTSCH. Echinacea alkylamides modulate TNF-α gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways[J]. FEBS Letters, 2004, 577 3: 563-569. DOI:10.1016/j.febslet.2004.10.064
[2] STEFAN RADUNER. Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects.[J]. The Journal of Biological Chemistry, 2006, 281 20: 14192-14206. DOI:10.1074/jbc.m601074200 |
| | Dodeca-2(E),4(E)-dienoic acid isobutylamide(p) Preparation Products And Raw materials |
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