- 6-Amino-1-methyluracil
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- $1.00 / 1kg
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2019-07-06
- CAS:2434-53-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: Customized
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| | 6-Amino-1-methyluracil Basic information |
| | 6-Amino-1-methyluracil Chemical Properties |
| Melting point | 300 °C | | density | 1.339±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Soluble in diluted sodium hydroxide solution. | | form | powder to crystal | | pka | 9.26±0.40(Predicted) | | color | White to Almost white | | BRN | 127771 | | InChI | InChI=1S/C5H7N3O2/c1-8-3(6)2-4(9)7-5(8)10/h2H,6H2,1H3,(H,7,9,10) | | InChIKey | GZLZRPNUDBIQBM-UHFFFAOYSA-N | | SMILES | C1(=O)N(C)C(N)=CC(=O)N1 | | CAS DataBase Reference | 2434-53-9(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 29335990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 6-Amino-1-methyluracil Usage And Synthesis |
| Chemical Properties | almost white to slightly beige crystalline powder | | Uses | 6-Amino-1-methyluracil is known to exert inhibitory effects towards DNA repair glycosylase. It is also known to be used as a flame retardant. | | Uses | 6-Amino-1-methyluracil may be used in the preparation of 1,1-di methyl-1H-spiro[pyrimido[4,5-b]quinoline-5,5-pyrrolo[2,3-d]pyrimidine]-2,2,4,4,6(1H,3H,3H,7H,1H)-pentaone, via reaction with isatin in the presence of catalytic p-toluene sulfonic acid. | | General Description | 6-Amino-1-methyluracil is an amino derivative of uracil and its standard molar enthalpy of combustion has been evaluated. Host-guest complexation of 6-amino-1-methyluracil with tetrapropoxycalix[4]arene has been reported. | | Synthesis | GENERAL METHOD: Ethyl cyanoacetate (0.1 mol) was mixed with N-methylurea (0.1 mol) in anhydrous ethanol (290 mL) containing sodium, and the reaction was carried out with reference to literature methods 26-34. The reaction mixture was refluxed for 10-12 hours and subsequently cooled to room temperature. Acidification was carried out by adjusting the pH to 6 with acetic acid. The resulting precipitate was washed with distilled water and dried in a desiccator overnight. | | References | [1] Journal of Medicinal Chemistry, 1999, vol. 42, # 13, p. 2344 - 2350
[2] RSC Advances, 2015, vol. 5, # 28, p. 21464 - 21470
[3] Chemical and Pharmaceutical Bulletin, 2013, vol. 61, # 4, p. 477 - 482
[4] Journal of Chemical Research, 2016, vol. 40, # 12, p. 771 - 777
[5] Patent: EP3299371, 2018, A1. Location in patent: Paragraph 0587; 0588 |
| | 6-Amino-1-methyluracil Preparation Products And Raw materials |
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