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Product Name:13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2
CAS:59894-07-4
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BOC Sciences
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Product Name:13,14-dihydro-15-keto prostaglandin D2
CAS:59894-07-4
Purity:95% Package:1G;10G;100G Remarks:13,14-dihydro-15-keto prostaglandin D2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. It has been recently identified as a selective agonist for the DP2 receptor. Additio
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Product Name:13,14-dihydro-15-keto Prostaglandin D2
CAS:59894-07-4
Purity:>98% Package:1mg;10mg;50mg;100mg;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Product Name:13,14-dihydro-15-keto Prostaglandin D2
CAS:59894-07-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 Basic information |
| Product Name: | 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 | | Synonyms: | 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2;9ALPHA-HYDROXY-11,15-DIOXO-PROST-5Z-EN-1-OIC ACID;(5Z,9α)-9-Hydroxy-11,15-dioxoprost-5-en-1-oic acid;13,14-Dihydro-15-ketoprostadlandin D2;DK-PGD2;13,14-dihydro-15-keto Prostaglandin D2 Lipid Maps MS Standard;13,14-dihydro-15-keto Prostaglandin D2;13,14-dihydro-15-keto Prostaglandin D2 MaxSpecStandard | | CAS: | 59894-07-4 | | MF: | C20H32O5 | | MW: | 352.47 | | EINECS: | | | Product Categories: | | | Mol File: | 59894-07-4.mol |  |
| | 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 Chemical Properties |
| Boiling point | 542.1±40.0 °C(Predicted) | | density | 1.086±0.06 g/cm3(Predicted) | | solubility | DMF: 50 mg/ml
DMSO: 30 mg/ml
Ethanol: 50 mg/mlPBS pH 7.2: 2.5 mg/ml | | pka | 4.76±0.10(Predicted) |
| | 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 Usage And Synthesis |
| Description | 13,14-dihydro-15-keto Prostaglandin D2 (13,14-dihydro-15-keto PGD2) is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor. It also inhibits ion flux in a canine colonic mucosa preparation. In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine. | | Uses | 13,14-Dihydro-15-keto-PGD2 is a metabolite of Prostaglandin D2 (CAT# P838575) and a selective CRTh2/DP2 receptor agonist. CRTh2/DP2 receptors play crucial roles in atopic dermatitis, asthma, and other inflammatory diseases. | | Definition | ChEBI: 13,14-dihydro-15-ketoprostaglandin D2 is a prostaglandins D. It has a role as a metabolite. It is functionally related to a prostaglandin D2. | | References | [1] P K RANGACHARI P A B. Biological activity of metabolites of PGD2 on canine proximal colon.[J]. American Journal of Physiology, 1993, 264 5 Pt 1: G886-94. DOI: 10.1152/ajpgi.1993.264.5.g886
[2] H. HIRAI. Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2[J]. The Tokushima journal of experimental medicine, 2001, 1 1: 255-262. DOI: 10.1084/jem.193.2.255
[3] T E LISTON L J R. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer.[J]. The Journal of Biological Chemistry, 1985, 260 24: 13172-13180.
[4] JASON D. MORROW. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay[J]. Analytical biochemistry, 1991, 193 1: Pages 142-148. DOI: 10.1016/0003-2697(91)90054-w
[5] DAVID MERIWETHER. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.[J]. Journal of Clinical Investigation, 2019, 129 9: 3670-3685. DOI: 10.1172/jci123700
[6] VICTORIA GÓMEZ-ABELLÁN . Professional phagocytic granulocyte-derived PGD2 regulates the resolution of inflammation in fish[J]. Developmental and comparative immunology, 2015, 52 2: Pages 182-191. DOI: 10.1016/j.dci.2015.04.017
[7] RALF SCHRÖDER. PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.[J]. PLoS ONE, 2012: e33329. DOI: 10.1371/journal.pone.0033329 |
| | 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 Preparation Products And Raw materials |
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