1-苯基双胍
| 中文名称 | 1-苯基双胍 |
|---|---|
| 中文同义词 | 苯基双胍;1-苯基双胍;1-PHENYLBIGUANIDE,5-HT3 RECEPTOR激动剂;1-苯基双胍,10 MM DMSO 溶液;1-Phenylbiguanide :1-苯基双胍;1-Phenylbiguanide :1-苯基双胍 |
| 英文名称 | PHENYLBIGUANIDE |
| 英文同义词 | phenyldiguanide;1-PHENYLBIGUANIDE;N-PHENYLIMINODICARBONIMIDIC-DIAMIDE;PHENYLBIGUANIDE;2-(N2-Phenylamidino)guanidine;1-phenyl-biguanid;n-phenyl-n’-guanylguanidine;p1426 |
| CAS号 | 102-02-3 |
| 分子式 | C8H11N5 |
| 分子量 | 177.21 |
| EINECS号 | 202-998-5 |
| 相关类别 | 胍;有机化学;AgonistsOrganic Building Blocks;Guanidines;Neurotransmitters;Nitrogen Compounds;Serotonergics |
| Mol文件 | 102-02-3.mol |
| 结构式 |  |
1-苯基双胍 性质
| 熔点 | 135-142 °C (lit.) |
|---|---|
| 沸点 | 299.13°C (rough estimate) |
| 密度 | 1.2512 (rough estimate) |
| 折射率 | 1.6900 (estimate) |
| 储存条件 | Keep in dark place,Sealed in dry,Room Temperature |
| 溶解度 | 易溶于酒精 |
| 酸度系数(pKa) | 10.76, 2.13(at 25℃) |
| 形态 | 粉末晶体 |
| 颜色 | 白色至橙色再至绿色 |
| Merck | 14,7276 |
| InChI | 1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13) |
| InChIKey | CUQCMXFWIMOWRP-UHFFFAOYSA-N |
| SMILES | NC(=N)\N=C(/N)Nc1ccccc1 |
| CAS 数据库 | 102-02-3(CAS DataBase Reference) |
| Target | Value |
|
5-HT3 receptor
(Cell-free assay) | 3.0 μM(EC50) |
Phenylbiguanide (1-Phenylbiguanide) is a 5-HT 3 receptor selective agonist with pEC 50 s of 5.57, 4.07, and 4.47 for r5-HT 3A(b) , h5-HT 3A , m5-HT 3A(b) , respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01).
In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | DU2450000 |
| 海关编码 | 2925.29.6000 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
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英文
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