H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH manufacturers
- (Arg)9
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- $0.00 / 100mg
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2026-01-05
- CAS:143413-47-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Basic information |
| | H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Chemical Properties |
| density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | Sequence | H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH |
| | H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Usage And Synthesis |
| Uses | (Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model[1][2]. | | Biological Activity | (Arg)9 (Nona-L-arginine; Peptide R9) is a cell-permeable polypeptide with IC50 value of 0.78 μM for neuroprotection in a glutamate model experimental model. | | in vitro | Poly-arginine (eg (Arg)9) and arginine-rich peptides (eg TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. It provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC 50 =0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC 50 =0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC 50 =6 μM). | | in vivo | (Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after reduces permanent middle cerebral artery occlusion (MCAO) infarct volume . | | target | IC50: 0.78 μM (neuroprotection) | | References | [1] Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9. DOI:10.1074/jbc.M003848200
[2] Meloni BP, et, al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34(2):173-81. DOI:10.1007/s10571-013-9999-3
[3] Meloni BP, et, al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35(6):993-1004. DOI:10.1038/jcbfm.2015.11 |
| | H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Preparation Products And Raw materials |
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