| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
Guanabenz hydrochloride manufacturers
|
| | Guanabenz hydrochloride Basic information |
| Product Name: | Guanabenz hydrochloride | | Synonyms: | Hydrazinecarboximidamide, 2-(2,6-dichlorobenzylidene)-, hydrochloride;1-{[(2,6-Dichlorophenyl)methylidene]amino}guanidine Hydrochloride;Guanabenzhydrochloride(Wytensin);NE56490;inhibit,Guanabenz hydrochloride,antiparasitic,Inhibitor,Beta Receptor,Guanabenz,Parasite,Adrenergic Receptor,antihypertensive,high blood pressure;2-(2,6-Dichlorobenzylidene)hydrazine-1-carboximidamide hydrochloride;uanabenz HCl;Guanabenz hydrochloride, 10 mM in DMSO | | CAS: | 23113-43-1 | | MF: | C8H8Cl2N4.ClH | | MW: | 267.54 | | EINECS: | | | Product Categories: | | | Mol File: | 23113-43-1.mol |  |
| | Guanabenz hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≥4.3 mg/mL in H2O; ≥4.37 mg/mL in EtOH; ≥9.25 mg/mL in DMSO | | form | A crystalline solid | | color | White to off-white |
| | Guanabenz hydrochloride Usage And Synthesis |
| Description | Guanabenz is an α2-adrenergic receptor agonist (effective concentrations 10-100 nM) with hypotensive effects. It also competes for imidazoline I2-binding sites in brown adipose tissue (Ki = 97 nM). | | Uses | Guanabenz hydrochloride is an orally active α-2-adrenoceptor agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure[1][2][3]. | | in vitro | maximum concentrations of guanabenz in plasma (1.2 to 5.2 ng/ml) reached 2 to 5 hours after administration of capsules containing 16 or 32 mg of 14c-labelled guanabenz. guanabenz was 90% bound to human plasma proteins [1]. guanabenz competed for imidazoline i2-binding sites in brown adipose tissue with ki of 97 nm [3]. | | in vivo | Guanabenz hydrochloride (5 mg/kg/day; i.p.; for 3 weeks) can reproducibly reduce brain cyst burden[2].
Guanabenz hydrochloride (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice[2].
Guanabenz hydrochloride (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats[3]. | Animal Model: | BALB/cJ mice[2] | | Dosage: | 5 mg/kg | | Administration: | 5 mg/kg/day; i.p. ; for 3 weeks | | Result: | Reduced the latent brain cysts in both male and female BALB/cJ mice. |
| Animal Model: | BALB/cJ mice[2] | | Dosage: | 5 mg/kg; 10 mg/kg | | Administration: | 5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks | | Result: | Reversed parasite-induced hyperactivity to near-baseline levels. |
| Animal Model: | Cats[3] | | Dosage: | 100 and 320 μg/kg and 1 mg/kg | | Administration: | 100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min
| | Result: | Declined markedly blood pressure and nerve activity. |
| | IC 50 | Toxoplasma | | references | [1] holmes b, brogden r n, heel r c, et al. guanabenz[j]. drugs, 1983, 26(3): 212-229.
[2] aantaa r, marjam ki a, scheinin m. molecular pharmacology of α2-adrenoceptor subtypes[j]. annals of medicine, 1995, 27(4): 439-449.
[3] rmer l, wurster s, savola j m, et al. identification and characterization of the imidazoline i2b-binding sites in the hamster brown adipose tissue as a study model for imidazoline receptors[j]. archives of physiology and biochemistry, 2003, 111(2): 159-166. |
| | Guanabenz hydrochloride Preparation Products And Raw materials |
|