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| | 4-Pyridin-2-yl-thiazol-2-ylamine Basic information |
| Product Name: | 4-Pyridin-2-yl-thiazol-2-ylamine | | Synonyms: | 4-(2-PYRIDINYL)-1,3-THIAZOL-2-AMINE;4-PYRIDIN-2-YL-1,3-THIAZOL-2-AMINE;2-AMINO-4-(2-PYRIDYL)THIAZOLE;IFLAB-BB F0447-0233;BUTTPARK 29\06-84;TIMTEC-BB SBB010613;4-(Pyridin-2-yl)thiazol-2-amine;4-(2-pyridyl)-2-thiazolamine | | CAS: | 30235-26-8 | | MF: | C8H7N3S | | MW: | 177.23 | | EINECS: | | | Product Categories: | | | Mol File: | 30235-26-8.mol |  |
| | 4-Pyridin-2-yl-thiazol-2-ylamine Chemical Properties |
| Melting point | 173-174 °C(Solv: ethanol, 50% (64-17-5)) | | Boiling point | 383.6±17.0 °C(Predicted) | | density | 1.333±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | form | Solid | | pka | 3.40±0.10(Predicted) | | color | Pale brown |
| HazardClass | IRRITANT | | HS Code | 2934100090 |
| | 4-Pyridin-2-yl-thiazol-2-ylamine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 4-(pyridin-2-yl)thiazol-2-amine from 2-bromo-1-(2-pyridinyl)ethanone and thiourea (CAS: 17356-08-0): 2-bromo-1-(2-pyridinyl)ethanone (0.01 mol, ca. 0.76 g), thiourea (0.01 mol), and 50 mL of ethanol were added to a 100 mL round-bottomed flask, and the mixture was heated to reflux for for 4 hours. After completion of the reaction, the ethanol solvent was removed by distillation under reduced pressure. The crude product was purified by column chromatography using dichloromethane (DCM): methanol (MeOH): ammonium hydroxide (NH4OH) (20:1:0.1, v/v) as mobile phase. 4-(Pyridin-2-yl)thiazol-2-amine was finally obtained as a white solid in a yield of 1.41 g in 79.6%. | | References | [1] Patent: CN105820163, 2016, A. Location in patent: Paragraph 0127 - 0129
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 2, p. 560 - 564
[3] Patent: WO2008/122787, 2008, A1. Location in patent: Page/Page column 85
[4] Journal of Heterocyclic Chemistry, 1970, vol. 7, p. 1137 - 1141
[5] Journal of the Chinese Chemical Society, 2017, vol. 64, # 12, p. 1408 - 1416 |
| | 4-Pyridin-2-yl-thiazol-2-ylamine Preparation Products And Raw materials |
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