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| | 4-Pyridin-3-yl-thiazol-2-ylamine Basic information |
| Product Name: | 4-Pyridin-3-yl-thiazol-2-ylamine | | Synonyms: | 2-AMINO-4-(3-PYRIDYL)THIAZOLE;4-(3-PYRIDINYL)-1,3-THIAZOL-2-YLAMINE;BUTTPARK 33\12-84;IFLAB-BB F0537-0970;TIMTEC-BB SBB010098;4-(3-PYRIDINYL)-2-THIAZOLAMINE;4-pyridine-3-yl-thiazol-2-ylamine;2-Thiazolamine, 4-(3-pyridinyl)- | | CAS: | 30235-27-9 | | MF: | C8H7N3S | | MW: | 177.23 | | EINECS: | | | Product Categories: | | | Mol File: | 30235-27-9.mol |  |
| | 4-Pyridin-3-yl-thiazol-2-ylamine Chemical Properties |
| Melting point | 213 °C(Solv: ethanol (64-17-5)) | | Boiling point | 396.3±17.0 °C(Predicted) | | density | 1.333±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Solid | | pka | 3.33±0.10(Predicted) | | color | Pale brown |
| Hazard Codes | Xi | | HS Code | 2933399990 |
| | 4-Pyridin-3-yl-thiazol-2-ylamine Usage And Synthesis |
| Uses | It is used as a pharmaceutical intermediate. | | Synthesis | Step 2: Synthesis of 4-(pyridin-3-yl)thiazol-2-amine: 2-bromo-1-(pyridin-3-yl)ethanone (2 g, 1 eq.) was dissolved in ethanol (18.46 mL) followed by addition of thiourea (0.543 g, 0.7 eq.). The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the mixture was cooled to 4 °C. During this process, the product precipitated as dihydrobromide. The precipitate was collected by filtration and dried. The resulting 4-(pyridin-3-yl)thiazol-2-amine dihydrobromide was dissolved in warm water (11 mL) and stirred for 5 minutes. Subsequently, aqueous ammonium hydroxide solution (17 mL) was added to this solution and stirring was continued. At this point, the target product slowly precipitated as a yellow solid. The solid product was separated by filtration and dried under vacuum conditions to give 2 g of 4-(pyridin-3-yl)thiazol-2-amine in 56% yield. The product was analyzed by LCMS showing m/z of 178.01 (M + H); 1H NMR (400 MHz, CD3OD) data were as follows: δ 8.96 (d, J=0.80 Hz, 1H), 8.44 (dd, J=1.60,4.80 Hz, 1H), 8.19-8.22 (m, 1H), 7.43-7.47 (m, 1H), and 7.05 (s, 1H). | | References | [1] Patent: WO2014/74675, 2014, A1. Location in patent: Paragraph 00222
[2] Journal of Heterocyclic Chemistry, 1970, vol. 7, p. 1137 - 1141
[3] Patent: WO2012/82817, 2012, A1. Location in patent: Page/Page column 93-94
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 2, p. 560 - 564 |
| | 4-Pyridin-3-yl-thiazol-2-ylamine Preparation Products And Raw materials |
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