- N-Ethylmaleimide
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- $39.00 / 10mg
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2026-02-02
- CAS:128-53-0
- Min. Order:
- Purity: 99.92%
- Supply Ability: 10g
- N-Ethylmaleimide
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- $0.00 / 25KG
-
2025-12-01
- CAS:128-53-0
- Min. Order: 1KG
- Purity: 98
- Supply Ability: 10000KGS
- N-Ethylmaleimide
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- $15.00 / 1KG
-
2021-07-13
- CAS:128-53-0
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | N-Ethylmaleimide Basic information |
| | N-Ethylmaleimide Chemical Properties |
| Melting point | 43-46 °C(lit.) | | Boiling point | 210 °C(lit.) | | density | 1.2500 (rough estimate) | | refractive index | 1.4430 (estimate) | | Fp | 73 °C | | storage temp. | 2-8°C | | solubility | methanol: 1 M at 20 °C, clear, colorless | | form | Crystalline Powder | | pka | -2.18±0.20(Predicted) | | color | White to off-white | | biological source | synthetic (organic) | | Water Solubility | 1 g/L (20 ºC) | | Sensitive | Light Sensitive | | Merck | 14,3822 | | BRN | 112448 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate. | | InChI | 1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3 | | InChIKey | HDFGOPSGAURCEO-UHFFFAOYSA-N | | SMILES | CCN1C(=O)C=CC1=O || CCN1C(=O)C=CC1=O | | CAS DataBase Reference | 128-53-0(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-pyrrole-2,5-dione, 1-ethyl-(128-53-0) | | EPA Substance Registry System | N-Ethylmaleimide (128-53-0) | | Absorption | cut-off at 382nm in methanol at 1M |
| Hazard Codes | T+ | | Risk Statements | 21-28-34-43-20/21 | | Safety Statements | 26-28-36/37/39-45-28A | | RIDADR | UN 2928 6.1/PG 2 | | WGK Germany | 3 | | RTECS | UX9625000 | | F | 19 | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | II | | HS Code | 29251900 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Oral
Acute Tox. 3 Dermal
Eye Dam. 1
Skin Corr. 1B
Skin Sens. 1 |
| | N-Ethylmaleimide Usage And Synthesis |
| Chemical Properties | White solid | | Uses | Reagent for the covalent modification of cysteine residues in proteins.
NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH. | | Uses | In cancer research (possible antimitotic activity.) | | Uses | N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg2+ dependent internucleosomal DNA fragmentation. | | Definition | ChEBI: N-ethylmaleimide is a member of the class of maleimides that is the N-ethyl derivative of maleimide. It has a role as an EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor, an EC 2.7.1.1 (hexokinase) inhibitor, an EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor and an anticoronaviral agent. It is functionally related to a maleimide. | | Hazard | Lachrymator when liquid, a strong irritant. | | Biochem/physiol Actions | Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels. | | Safety Profile | Poison by
intraperitoneal route. Human mutation data
reported. Vapors are hlghly irritating. When
heated to decomposition it emits toxic
fumes of NOx. |
| | N-Ethylmaleimide Preparation Products And Raw materials |
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