Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)-

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Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)- Suppliers list
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Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)- Basic information
Product Name:Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)-
Synonyms:Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)-;CRV431;Rencofilstat
CAS:1383420-08-3
MF:C67H122N12O13
MW:1303.76
EINECS:
Product Categories:
Mol File:1383420-08-3.mol
Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)- Structure
Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)- Chemical Properties
Boiling point 1362.6±65.0 °C(Predicted)
density 1.017±0.06 g/cm3(Predicted)
pka13.33±0.70(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)- Usage And Synthesis
UsesRencofilstat (CRV431) is a pan-cyclophilin inhibitor with IC50 values of 2.5 nM, 3.1 nM, 2.8 nM, 7.3 nM for Cyp A, CypB, Cyp D and Cyp G, respectively. Rencofilstat reduces fibrosis and tumor growth in models of chronic liver disease[1].
in vivo

Rencofilstat (50 mg/kg, po, daily for 8 weeks) exhibits anti-fibtosis and antitumor activities in the mouse nonalcoholic steatohepatitis (NASH) model[1].

Animal Model:Mouse nonalcoholic steatohepatitis (NASH) model[1]
Dosage:50 mg/kg
Administration:po, daily for 8 weeks
Result:Decreased liver fibrosis, reduced the number and size of liver tumors.
IC 50Cyclophilin A: 2.5 nM (IC50); Cyclophilin B: 3.1 nM (IC50); Cyclophilin D: 2.8 nM (IC50); Cyclophilin G: 7.3 nM (IC50)
References[1] Joseph Kuo, et al. A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models. J Pharmacol Exp Ther. 2019 Nov;371(2):231-241.
Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)- Preparation Products And Raw materials
Tag:Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)-(1383420-08-3) Related Product Information
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