| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:7α-Chloro-16α-Methyl Prednisolone
CAS:67452-97-5
Package:10Mg,25Mg,5Mg
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:7α-Chloro-16α-Methyl Prednisolone;(7α,11β,16α)-7-Chloro-11,17,21-trihydroxy-16-Methylpregna-1,4-diene-3,20-dione; 7α-Chloro-16α-Methylprednisolone; AlcloMetasone; AlcloMethasone;
CAS:67452-97-5
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| | Alclometasone Basic information |
| Product Name: | Alclometasone | | Synonyms: | ALCLOMETHASONE DIPROPIONATE;7α-Chloro-16α-methylprednisolone;7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione;Alclometasone;Vaderm;(7α,11β,16α)-7-Chloro-11,17,21-trihydroxy-16-Methylpregna-1,4-diene-3,20-dione;AlcloMethasone;Pregna-1,4-diene-3,20-dione, 7-chloro-11,17,21-trihydroxy-16-methyl-, (7α,11β,16α)- | | CAS: | 67452-97-5 | | MF: | C22H29ClO5 | | MW: | 408.919 | | EINECS: | | | Product Categories: | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids | | Mol File: | 67452-97-5.mol |  |
| | Alclometasone Chemical Properties |
| Melting point | 176-179° | | alpha | D26 +47.5° (c = 0.3 in DMF) | | Boiling point | 607.1±55.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | pka | 12.30±0.70(Predicted) |
| | Alclometasone Usage And Synthesis |
| Uses | As a metabolite of Alclometasone dipropionate; Alclometasone can be used as a synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. | | Uses | A metabolite of Alclometasone dipropionate (A514580); a synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. | | Definition | ChEBI: A prednisolone compound having an alpha-chloro substituent at the 7-position and an alpha-methyl substituent at the 16-position. | | Brand name | Aclovate
(GlaxoSmithKline). | | in vivo | The prodrug of alclometasone is alclometasone dipropionate[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice[2]. |
| | Alclometasone Preparation Products And Raw materials |
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