VU-0486321

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VU-0486321 Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Company Name: NanJing Xienuo bio Co.,Ltd.  
Tel: 025-84112752 13805181430
Email: 154301870@qq.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354;
Email: support@targetmol.com

VU-0486321 manufacturers

  • VU0486321
  • VU0486321 pictures
  • $1980.00
  • 2026-07-15
  • CAS:1816301-67-3
  • Purity:
  • Supply Ability: 10g
VU-0486321 Basic information
Product Name:VU-0486321
Synonyms:VU-0486321;2-Furancarboxamide, N-[3-chloro-4-(4-fluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-3-methyl-
CAS:1816301-67-3
MF:C20H12ClFN2O4
MW:398.77
EINECS:
Product Categories:
Mol File:1816301-67-3.mol
VU-0486321 Structure
VU-0486321 Chemical Properties
density 1.528±0.06 g/cm3(Predicted)
form Solid
pka11.68±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
VU-0486321 Usage And Synthesis
DescriptionVU0486321 is a potent mGlu1 PAM with moderate rat PK (CLp = 13.3. mL/mikg,t1/2 = 54 min), good free fraction (human fu = 0.05, rat fu =0.03) and excellent CNS penetration (Kp = 1.02).
UsesVU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity.
References[1] Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs
VU-0486321 Preparation Products And Raw materials
Tag:VU-0486321(1816301-67-3) Related Product Information
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