N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide Suppliers list

Company Name:	Fuxin Pharmaceutical
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Email:	contact@fuxinpharm.com
Products Intro:	CAS:1135243-19-4 Purity:99% Package:1kg; 25kg; or larger package as required

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354; +17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:VU 0255035 CAS:1135243-19-4 Purity:98.26% Package:5mg;43USD\|10mg;73USD\|25mg;155USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	Hefei TNJ Chemical Industry Co.,Ltd.
Tel:	+86-0551-65418684 +8618949823763
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Products Intro:	Product Name:N-{3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl}-2,1,3-benz... CAS:1135243-19-4

Company Name:	Wuhan Topule Biopharmaceutical Co., Ltd
Tel:	+8618327326525
Email:	masar@topule.com
Products Intro:	Product Name:VU 0255035 CAS:1135243-19-4 Purity:98%+ Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing

Company Name:	Aladdin Scientific
Tel:
Email:	tp@aladdinsci.com
Products Intro:	Product Name:VU0255035 CAS:1135243-19-4 Purity:>=98% Package:$42.9/2mg;$88.9/5mg;$147.9/10mg;$310.9/25mg;$559.9/50mg;$1007.9/100mg;$2267.9/25 Remarks:98%

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide manufacturers

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide Basic information

Product Name:	N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide
Synonyms:	N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide;VU 0255035;N-(3-Oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonaMide;CID24768606;ML012;N-(3-oxo-3-(4-(pyridine-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide hydrate;N-[3-oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide hydrate;VU0255035 hydrate
CAS:	1135243-19-4
MF:	C18H20N6O3S2
MW:	432.52
EINECS:
Product Categories:
Mol File:	1135243-19-4.mol

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide Chemical Properties

Melting point	159.7-160.2 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
Boiling point	689.3±65.0 °C(Predicted)
density	1.447±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: >5mg/mL
form	powder
pka	8.97±0.50(Predicted)
color	yellow

Safety Information

MSDS Information

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide Usage And Synthesis

Uses	VU 0255035 is a novel, selective antagonist of M1 mAChRs, which has potential treatment in CNS disorders.
Definition	ChEBI: N-[3-oxo-3-(4-pyridin-4-yl-1-piperazinyl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide is a member of pyridines and a member of piperazines.
Biological Activity	VU0255035 is the first highly selective antagonist at the orthosteric site of the M1 receptor (75-fold selective for M1 relative to other muscarininc subtypes and devoid of activity at other GPCRs, ion channels, transporters and kinases). There are no highly selective M1 muscarinic receptor antagonists. The existing non-selective drugs do not permit direct evaluation of the role of M1 receptors in CNS fucntions and do not premit therapeutic targeting of M1 receptors in various disease states in which M1 receptors are implicated (epilepsy, Parkinsonμs disease, attention and cognitive disorders, dystonia, etc).
storage	Store at -20°C

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide Preparation Products And Raw materials

Tag:N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide(1135243-19-4) Related Product Information

VU 0364770 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide VU 0365114 VU 0357017 hydrochloride VU 0463841 [Hexahydro-5-(4-pyridinyl)pyrrolo[3,4-c]pyrrol-2(1H)-yl][1-(5-isoquinolinylsulfonyl)-3-azetidinyl]-Methanone N-(5-chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide VU0453595 VU 0364439 5-[1-(2-ethoxyphenyl)sulfonylazetidin-3-yl]-3-thiophen-3-yl-1,2,4-oxadiazole VU 0360223 2(5H)-Furanone, 3-(3-fluorophenyl)-4-(4-methoxyphenyl)- VU 0360172 cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide Urea, N-(3,4-difluorophenyl)-N'-[3-methyl-1-(phenylmethyl)-1H-pyrazol-5-yl]- VU-0486321 VU0238441

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