Thiobenzanilide-63T manufacturers
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| | Thiobenzanilide-63T Basic information |
| Product Name: | Thiobenzanilide-63T | | Synonyms: | 63T;Thiobenzanilide 63T;Thiobenzanilide63T;Thiobenzanilide-63T;Benzenecarbothioamide, N,N'-1,2-phenylenebis[3,4,5-trifluoro- | | CAS: | 1270966-08-9 | | MF: | C20H10F6N2S2 | | MW: | 456.43 | | EINECS: | | | Product Categories: | | | Mol File: | 1270966-08-9.mol |  |
| | Thiobenzanilide-63T Chemical Properties |
| Melting point | 184-187 °C | | Boiling point | 491.2±55.0 °C(Predicted) | | density | 1.583±0.06 g/cm3(Predicted) | | pka | 8.38±0.70(Predicted) |
| | Thiobenzanilide-63T Usage And Synthesis |
| Description | Thiobenzanilide 63T is a small molecule compound, which selectively induces cancer cell death in a caspase independent pathway. | | Uses | Thiobenzanilide 63T (63T) is a small molecule that selectively induces cancer cell death in a caspase-independent pathway. Thiobenzanilide 63T induces reactive oxygen species and lipid peroxidation. Thiobenzanilide 63T demonstrates strong cytotoxic activity against a lung-derived cancer cell line. Thiobenzanilide 63T decreases the expression of heme oxygenase (HO-1) in A549 cells[1][2]. | | References | [1] Kucinska M, et al. Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells. Toxicol In Vitro. 2016 Dec;37:148-161. DOI:10.1016/j.tiv.2016.09.017
[2] Kucinska M, et al. The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines. Invest New Drugs. 2019 Oct;37(5):849-864. DOI:10.1007/s10637-018-0704-8 |
| | Thiobenzanilide-63T Preparation Products And Raw materials |
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