- Pseudolaric acid B
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- $10.00
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2026-03-20
- CAS:82508-31-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- Pseudolaric Acid B
-
-
2023-02-24
- CAS:82508-31-4
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
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| | Pseudolaric acid B Basic information |
| Product Name: | Pseudolaric acid B | | Synonyms: | Pseudolaric acid;Pseudolaric Acid B
(PAB);Pseudolaric Acid B(PBA);-1,3-pentadienyl)3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methylester,(3-al;1h-4,9a-ethanocyclohepta(c)pyran-7-carboxylicacid,4a-(acetyloxy)-3-(4-carboxy;pha(1e,3e),4-alpha,4a-alpha,9a-alpha)-(-)-(9ci);PLAB;1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylicacid,4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methyl ester, (3R,4S,4aS,9aR)- | | CAS: | 82508-31-4 | | MF: | C23H28O8 | | MW: | 432.46 | | EINECS: | 231-291-4 | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors | | Mol File: | 82508-31-4.mol |  |
| | Pseudolaric acid B Chemical Properties |
| Melting point | 166°C | | Boiling point | 466.14°C (rough estimate) | | density | 1.2108 (rough estimate) | | refractive index | 1.4480 (estimate) | | storage temp. | 2-8°C | | solubility | methanol: soluble1mg/mL, clear, colorless | | form | powder or crystals | | pka | 4.52±0.19(Predicted) | | color | white to off-white | | InChIKey | VDGOFNMYZYBUDT-YCONPBHISA-N | | SMILES | C1(=O)O[C@@](/C=C/C=C(/C(O)=O)\C)(C)[C@]2([H])CC[C@@]31CC=C(C(OC)=O)CC[C@@]32OC(C)=O |
| Hazard Codes | T | | Risk Statements | 25-62 | | Safety Statements | 36/37-45-24/25 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | HS Code | 29329990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Repr. 2 | | Hazardous Substances Data | 82508-31-4(Hazardous Substances Data) |
| | Pseudolaric acid B Usage And Synthesis |
| Description | Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities, consistent with its traditional use in the treatment of dermatological fungal infections. Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo. | | Chemical Properties | White crystalline powder, soluble in chloroform, acetone and methanol, derived from the bark of the Chinese thorn tree and the golden pine. | | Uses | (-)-Pseudolaric Acid B is a diterpenoid posessing an immunomodulatory effect. It acts as an immunosuppressant in vitro/vivo however does show some cytotoxicity. Anti-tumor agent as well. | | Definition | ChEBI: Pseudolaric acid B is a diterpene lactone. | | in vivo | Pseudolaric Acid B (Oral gavage; 10-20 mg/kg; 3 days) has anti-fertility ability in rats, which may be related to the maternal vascular system[4]. | | IC 50 | HIF-1α | | References | [1] ERGUANG LI Charles D H Alice M Clark. Antifungal Evaluation of Pseudolaric Acid B, a Major Constituent of Pseudolarix kaempferi[J]. Journal of Natural Products , 1995, 58 1: 57-67. DOI: 10.1021/np50115a007
[2] XIANFENG GONG. Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death[J]. Experimental and Molecular Medicine, 2006, 38 4: 428-434. DOI: 10.1038/emm.2006.50
[3] VINCENT K W WONG. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo.[J]. Clinical Cancer Research, 2005, 11 16: 6002-6011. DOI: 10.1158/1078-0432.ccr-05-0209
[4] MEI-HONG LI. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation.[J]. Clinical Cancer Research, 2004, 10 24: 8266-8274. DOI: 10.1158/1078-0432.ccr-04-0951 |
| | Pseudolaric acid B Preparation Products And Raw materials |
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