3,6-Dibromo-alpha-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride

3,6-Dibromo-alpha-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride Suppliers list

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	18930552037
Email:	3bsc@sina.com

Company Name:	Nanjing Chemlin Chemical Co., Ltd
Tel:	025-83697070 13770331960
Email:	info@chemlin.com.cn

3,6-Dibromo-alpha-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride manufacturers

3,6-Dibromo-alpha-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride Basic information

Product Name:	3,6-Dibromo-alpha-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride
Synonyms:	BAX CHANNEL BLOCKER;Baxchannelblocker2HCl;3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanoldihydrochloride;Bax channel blocke;Bax channel blocker(BAI-1);1-(3,6-Dibromo-9H-carbazoL;9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-;)-3-(piperazin-1-yL
CAS:	335165-68-9
MF:	C19H21Br2N3O
MW:	467.2
EINECS:
Product Categories:	Caspases/Apoptosis;Apoptosis Inhibitors
Mol File:	335165-68-9.mol

3,6-Dibromo-alpha-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride Chemical Properties

Boiling point	388.1±42.0 °C(Predicted)
density	1.71±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	≥28.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
form	solid
pka	14.48±0.20(Predicted)
color	White
InChI	InChI=1S/C19H21Br2N3O.2ClH/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23;;/h1-4,9-10,15,22,25H,5-8,11-12H2;2*1H
InChIKey	HWFKCAFKXZFOQT-UHFFFAOYSA-N
SMILES	C12=CC=C(Br)C=C1C1=C(C=CC(Br)=C1)N2CC(O)CN1CCNCC1.Cl.Cl

Safety Information

MSDS Information

3,6-Dibromo-alpha-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride Usage And Synthesis

Uses	Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release.
Biological Activity	Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC 50 = 0.52 μ M). Suggested to inhibit Bax channel formation/activity.
in vitro	bax channel blocker, a 3,6-dibromocarbazole derivative, was observed to inhibit cytochrome c releasing from mitochondria by bax channel modulation. the monohydroxy analogue bax channel blocker remained the unprecedented inhibition of bax-induced cytochrome c release at 10 μm. the ic50 value of bax channel blocker was determined to be 0.52 μm, indicating that bax channel blocker was a bax channel inhibitor as hypothesized. moreover, in the liposome assay, bax channel blocker showing significant inhibition (>65%) of cytochrome c release at 10 μm also demonstrated sub-micromolar ic50 value [1].
IC 50	0.52 μm in bax assay
references	[1] bombrun a,gerber p,casi g,terradillos o,antonsson b,halazy s. 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via bax channel modulation. j med chem.2003 oct 9;46(21):4365-8.

3,6-Dibromo-alpha-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride Preparation Products And Raw materials

Raw materials

Tag:3,6-Dibromo-alpha-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride(335165-68-9) Related Product Information

3-(1H-Indol-1-yl)propan-1-amine hydrochloride 5-Bromo-1-ethyl-1H-indole 1-n-Propylpiperazine dihydrobromide 1-Propyl-piperazine monohydrobromide 1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(dimethylamino)propan-2-ol 3,6-Dibromo-alpha-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride 1-(4-[2-Hydroxy-3-(1,3,6-tribromo-9H-carbazol-9-yl)propyl]piperazino)-3-(1,3,6-tribromo-9H-carbazol-9-yl)propan-2-ol dihydrochloride Carbazole-9-ethanol 5-Bromo-1-methyl-1H-indole 3,6-Dibromo-9-ethylcarbazole 3-Bromo-9H-carbazole 3,6-Dibromocarbazole