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(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol

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(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol manufacturers
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol Basic information
Product Name:(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
Synonyms:ACOLBIFENE (hydrochloride);BYQDPIXWTVEVEA-JMAPEOGHSA-N;(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol;(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol,hydrochloride
CAS:252555-01-4
MF:C29H31NO4
MW:0
EINECS:
Product Categories:
Mol File:252555-01-4.mol
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol Structure
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol Chemical Properties
solubility DMSO: 180 mg/mL (364.36 mM)
form Solid
color White to yellow
Safety Information
MSDS Information
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol Usage And Synthesis
UsesPrevention or treatment of breast and uterine proliferation or cancer.
in vivo

Acolbifene (ACOL) reduces food intake and strongly decreases cholesterolemia in rats fed a cholesterol-free diet[2].
Acolbifene (ACOL) reduces food intake (16%) and weight gain (45%, mainly fat) similarly in both dietary cohorts[2].

Animal Model:Female Sprague-Dawley rats (n = 42) initially weighing 175-200 g[2].
Dosage:2.5 mg/kg.
Administration:Oral gavage, once daily for 21 d.
Result:Prevents tumor growth in rats.
IC 50ERα: 2 nM (IC50, E2-induced transcriptional activity); ERβ: 0.4 nM (IC50, E2-induced transcriptional activity)
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol Preparation Products And Raw materials
Raw materialsSch 57068
Tag:(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol(252555-01-4) Related Product Information
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