Sch 57068 manufacturers
- Acolbifene
-
- $76.00
-
2026-07-27
- CAS:182167-02-8
- Purity: 98.17%
- Supply Ability: 10g
- Acolbifene
-
- $76.00
-
2026-07-27
- CAS:182167-02-8
- Purity: 98.17%
- Supply Ability: 10g
- Acolbifene
-
- $76.00
-
2026-07-14
- CAS:182167-02-8
- Purity: 98.17%
- Supply Ability: 10g
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| | Sch 57068 Basic information |
| Product Name: | Sch 57068 | | Synonyms: | ( )-(2S)-3-(4-Hydroxyphenyl)-4-methyl-2-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-1-benzopyran-7-ol;2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-(4-(2-(1-piperidinyl)ethoxy)phenyl)-, (S)-;Em 652;Em-652;Sch 57068;(S)-3-(4-hydroxyphenyl)-4-Methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol;ACOLBIFENE;EM652;Acolbifene (EM 652, SCH57068) | | CAS: | 182167-02-8 | | MF: | C29H31NO4 | | MW: | 457.56 | | EINECS: | | | Product Categories: | | | Mol File: | 182167-02-8.mol |  |
| | Sch 57068 Chemical Properties |
| Boiling point | 651.5±55.0 °C(Predicted) | | density | 1.217±0.06 g/cm3(Predicted) | | solubility | DMSO:50.0(Max Conc. mg/mL);109.28(Max Conc. mM) | | form | A solid | | pka | 9.70±0.40(Predicted) | | color | White to pink |
| | Sch 57068 Usage And Synthesis |
| Uses | Prevention
or treatment of breast and uterine proliferation or cancer. | | in vivo | Acolbifene (ACOL) reduces food intake and strongly decreases cholesterolemia in rats fed a cholesterol-free diet[2].
Acolbifene (ACOL) reduces food intake (16%) and weight gain (45%, mainly fat) similarly in both dietary cohorts[2].
| Animal Model: | Female Sprague-Dawley rats (n = 42) initially weighing 175-200 g[2]. | | Dosage: | 2.5 mg/kg. | | Administration: | Oral gavage, once daily for 21 d. | | Result: | Prevents tumor growth in rats. |
| | IC 50 | ERα: 2 nM (IC50, E2-induced transcriptional activity); ERβ: 0.4 nM (IC50, E2-induced transcriptional activity) |
| | Sch 57068 Preparation Products And Raw materials |
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