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| | Diphenylpiperidin-4-ylmethanol hydrochloride Basic information |
| Product Name: | Diphenylpiperidin-4-ylmethanol hydrochloride | | Synonyms: | AZACYCLONOL HYDROCHLORIDE;DIPHENYL-PIPERIDIN-4-YL-METHANOLHYDROCHLORIDE;ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL, HYDROCHLORIDE;alpha-(4-piperidyl)benzhydrolhydrochloride;alpha,alpha-diphenyl-4-piperidinemethanohydrochloride;alpha,alpha-diphenyl-4-piperidinemethanolhydrochloride;frenquelhydrochloride;gamma-pipradolhydrochloride | | CAS: | 1798-50-1 | | MF: | C18H22ClNO | | MW: | 303.83 | | EINECS: | 217-284-9 | | Product Categories: | | | Mol File: | 1798-50-1.mol |  |
| | Diphenylpiperidin-4-ylmethanol hydrochloride Chemical Properties |
| Provider | Language |
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ACROS
| English |
| | Diphenylpiperidin-4-ylmethanol hydrochloride Usage And Synthesis |
| Chemical Properties | white to off-white crystalline powder | | Originator | Frenquel,Merrell,US,1955 | | Manufacturing Process | A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum
oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen
at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours.
The solution is filtered and the filtrate evaprated under reduced pressure. The
residue is dissolved in a mixture of equal parts of methanol and butanone and
0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and
filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283-
285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment
with ammonia and when so obtained has a melting point of 160-161°C. | | Brand name | Frenquel (Marion Merrell
Dow). | | Therapeutic Function | Tranquilizer |
| | Diphenylpiperidin-4-ylmethanol hydrochloride Preparation Products And Raw materials |
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