- 4-Piperidinemethanol
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- $10.00 / 1KG
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2026-03-20
- CAS:6457-49-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100 mt
- 4-Piperidinemethanol
-
- $0.00 / 1g
-
2026-02-02
- CAS:6457-49-4
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 2000tons
- 4-Piperidinemethanol
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- $35.00 / 1kg
-
2025-09-25
- CAS:6457-49-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 4-Piperidinemethanol Basic information |
| | 4-Piperidinemethanol Chemical Properties |
| Melting point | 55-59 °C(lit.) | | Boiling point | 118-120 °C10 mm Hg(lit.) | | density | 0,997 g/cm3 | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | Water Solubility | Soluble in water | | form | Crystalline Powder, Chunks and/or Solid | | pka | 14.94±0.10(Predicted) | | color | White to off-white | | Sensitive | Hygroscopic | | BRN | 103071 | | InChI | InChI=1S/C6H13NO/c8-5-6-1-3-7-4-2-6/h6-8H,1-5H2 | | InChIKey | XBXHCBLBYQEYTI-UHFFFAOYSA-N | | SMILES | N1CCC(CO)CC1 | | CAS DataBase Reference | 6457-49-4(CAS DataBase Reference) |
| Hazard Codes | C,Xi | | Risk Statements | 34-22 | | Safety Statements | 26-27-36/37/39-45 | | RIDADR | UN 3263 8/PG 2 | | WGK Germany | 3 | | Hazard Note | Irritant/Hygroscopic | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29333990 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Skin Corr. 1B |
| | 4-Piperidinemethanol Usage And Synthesis |
| Chemical Properties | white to off-white crystalline powder, chunks | | Uses | 4-Piperidinemethanol may be used in the preparation of:
- N-tert-butoxycarbonyl-4-hydroxymethyl piperidine
- desferrioxamine B (DFO) containing third generation triazine dendrimer
- ethyl 3-(4-(hydroxymethyl)piperidin-1-yl)propanoate (EHMPP)
- 4-(hydroxymethyl)piperidine-1-carbodithioic acid (HL)
- 1-[[(1E)-2-(4-chlorophenyl)ethenyl]sulfonyl]-4-piperidinemethanol
| | General Description | 4-Piperidinemethanol is a cyclic secondary amine. Its standard molar enthalpies of combustion, sublimation and formation have been determined. | | Synthesis | The general procedure for the synthesis of 4-hydroxymethylpiperidine from ethyl 4-piperidinecarboxylate was as follows: lithium aluminum hydride (LiAlH4, 10.10 g, 0.266 mol) was suspended in tetrahydrofuran (THF, 150 mL) at 0 °C. Subsequently, a solution of ethyl 4-piperidinecarboxylate (18.13 g, 0.120 mol) dissolved in THF (300 mL) was slowly added. The reaction mixture was stirred at room temperature overnight. After the reaction was completed, it was cooled in an ice bath and a mixture of water (14 mL) and THF (28 mL) was slowly added. Next, a mixture of 15% aqueous sodium hydroxide (14 mL) and water (37 mL) was added and stirring was continued for 30 minutes at room temperature. The reaction mixture was filtered to remove the precipitate and the filtrate was concentrated to give 17.88 g of the target product 4-hydroxymethylpiperidine in quantitative yield. | | References | [1] Patent: WO2004/76450, 2004, A1. Location in patent: Page 59
[2] Patent: WO2010/12611, 2010, A1. Location in patent: Page/Page column 27
[3] RSC Advances, 2016, vol. 6, # 22, p. 17929 - 17940
[4] European Journal of Medicinal Chemistry, 2019, p. 234 - 248
[5] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 773 - 791 |
| | 4-Piperidinemethanol Preparation Products And Raw materials |
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