Benzamide, N-(2-hydroxyethyl)-2-methyl-3-[[4-[[3-(trifluoromethyl)phenyl]methyl]-2-pyridinyl]amino]-

Request For Quotation
Benzamide, N-(2-hydroxyethyl)-2-methyl-3-[[4-[[3-(trifluoromethyl)phenyl]methyl]-2-pyridinyl]amino]- Basic information
Product Name:Benzamide, N-(2-hydroxyethyl)-2-methyl-3-[[4-[[3-(trifluoromethyl)phenyl]methyl]-2-pyridinyl]amino]-
Synonyms:Benzamide, N-(2-hydroxyethyl)-2-methyl-3-[[4-[[3-(trifluoromethyl)phenyl]methyl]-2-pyridinyl]amino]-;PW0729
CAS:2767348-36-5
MF:C23H22F3N3O2
MW:429.44
EINECS:
Product Categories:
Mol File:2767348-36-5.mol
Benzamide, N-(2-hydroxyethyl)-2-methyl-3-[[4-[[3-(trifluoromethyl)phenyl]methyl]-2-pyridinyl]amino]- Structure
Benzamide, N-(2-hydroxyethyl)-2-methyl-3-[[4-[[3-(trifluoromethyl)phenyl]methyl]-2-pyridinyl]amino]- Chemical Properties
Boiling point 557.8±50.0 °C(predicted)
density 1.292±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka14.23±0.46(predicted)
Safety Information
MSDS Information
Benzamide, N-(2-hydroxyethyl)-2-methyl-3-[[4-[[3-(trifluoromethyl)phenyl]methyl]-2-pyridinyl]amino]- Usage And Synthesis
UsesPW0729 (compound 15b) is an orphan GPR52 agonist with potential applications in GPR52 activation, signaling bias, and neuropsychiatric and neurological disorders. The brain exposure characteristics of PW0729 need to be further optimized[1].
References[1] Murphy R E, Wang P, Ali S, et al. Discovery of 3-((4-Benzylpyridin-2-yl) amino) benzamides as Potent GPR52 G Protein-Biased Agonists[J]. Journal of Medicinal Chemistry, 2024.
Benzamide, N-(2-hydroxyethyl)-2-methyl-3-[[4-[[3-(trifluoromethyl)phenyl]methyl]-2-pyridinyl]amino]- Preparation Products And Raw materials
Tag:Benzamide, N-(2-hydroxyethyl)-2-methyl-3-[[4-[[3-(trifluoromethyl)phenyl]methyl]-2-pyridinyl]amino]-(2767348-36-5) Related Product Information
3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)- 9-Azabicyclo[3.3.1]nonane-9-acetamide, N-(2-chlorophenyl)-3-[(3,4,5-trimethoxybenzoyl)amino]-, (3-exo)- N-[[[[(4S)-3-(4-Chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl][[[4-(trifluoromethyl)phenyl]sulfonyl]amino]methylene]amino]iminomethyl]acetamide (4-chlorophenyl)(4-((2S,5R)-2-ethyl-4-(5-(5-(ethylamino)-1,3,4-oxadiazol-2-yl)-3-methylpyrazin-2-yl)-5-methylpiperazin-1-yl)piperidin-1-yl)methanone 3-amino-5-(4-benzylphenyl)thieno[2,3-d]pyrimidin-4(3H)-one TXNIP-IN-1