IEM 1460

Request For Quotation
IEM 1460 Suppliers list
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 18930552037
Email: 3bsc@sina.com
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
Email: info@emmx.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ：65489617 13301690235
Email: Sales@ATKchemical.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com

IEM 1460 manufacturers

  • IEM 1460
  • IEM 1460 pictures
  • $383.00
  • 2026-07-15
  • CAS:121034-89-7
  • Purity:
  • Supply Ability: 10g
IEM 1460 Basic information
Product Name:IEM 1460
Synonyms:IEM 1460;N,N,N-TRIMETHYL-5-[(TRICYCLO[3.3.1.13,7]DEC-1-YLMETHYL)AMINO]-1-PENTANAMINIUMBROMIDE HYDROBROMIDE;N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromidehydrobromide;5-(1-adamantylmethylamino)pentyl-trimethylazanium:bromide:hydrobromide;IEM-1460, GluR2 lacking AMPA receptor blocker
CAS:121034-89-7
MF:C19H38Br2N2
MW:454.34
EINECS:
Product Categories:Glutamate receptor
Mol File:121034-89-7.mol
IEM 1460 Structure
IEM 1460 Chemical Properties
storage temp. Desiccate at RT
solubility Soluble to 100 mM in water and to 100 mM in DMSO
form solid
color white
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
MSDS Information
IEM 1460 Usage And Synthesis
DescriptionIEM 1460 is an adamantine derivative that blocks both AMPA- and NMDA-type glutamate receptor (GluR) channels (IC50 = 10 μM-0.1 mM). It is selective for Ca2+-permeable GluR channels, which lack the GluR2 R subunit, and has been used to identify Ca2+-permeable glutamate receptors in the brain.
UsesIEM 1460 is an Adamantane derivative and open-channel blocker of AMPA currents.
Biological ActivityVoltage-dependent open-channel blocker of AMPA receptors. Displays selectivity between subtypes, blocking GluR2 subunit-lacking (Ca 2+ -permeable) receptors more potently than GluR2-containing receptors (IC 50 values are 2.6 and 1102 μ M respectively). Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo .
storageRoom temperature (desiccate)
References[1] FRIEDRICH SCHLESINGER. Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors[J]. British Journal of Pharmacology, 2009, 145 5: 656-663. DOI: 10.1038/sj.bjp.0706233
IEM 1460 Preparation Products And Raw materials
Tag:IEM 1460(121034-89-7) Related Product Information
1-Triethylammonio-5-(1-adamantane-methylammoniopentane)dibromide IEM 1460 (-)-BETA-HYDRASTINE IEM 1754 dihydrobroMide 2-Aminoethoxydiphenyl borate Benidipine hydrochloride