(-)-BETA-HYDRASTINE

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Company Name: Chengdu Biopurify Phytochemicals Ltd.
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Products Intro: Product Name:Hydrastine
CAS:118-08-1
Purity:>95%,98%,99% Package:From mgs to grams,up to Kgs Remarks:Can be customized in bulk scale
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Products Intro: Product Name:(-)-BETA-HYDRASTINE
CAS:118-08-1
Purity:0.98 Package:1KG;5KG;25KG
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CAS:118-08-1
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Products Intro: Product Name:(-)-Hydrastine
CAS:118-08-1
Purity:0.98 Package:10mg;20mg;50mg;100mg;200mg;500mg;1g;10g;100g;可按照客户要求定制包装
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Products Intro: Product Name:Hydrastine;118-08-1
CAS:118-08-1
Purity:0.99 Package:25KG,200L

(-)-BETA-HYDRASTINE manufacturers

  • Hydrastine
  • Hydrastine pictures
  • $52.00
  • 2026-06-02
  • CAS:118-08-1
  • Purity: 99.92%
  • Supply Ability: 10g
(-)-BETA-HYDRASTINE Basic information
Product Name:(-)-BETA-HYDRASTINE
Synonyms:HYDRASTINE, (-)-B-(P) (AHP Verified);HYDRASTINE, (-)-B-(P);HYDRASTINE (D-beta-);(-)-Β-HYDRASTINE;(1R;9S)-Β-HYDRASTINE;9S)-β-Hydrastine;N-Desmethyl β(+/-)-Nor-βHydrastine (base and/or unspecified salts)
CAS:118-08-1
MF:C21H21NO6
MW:383.39
EINECS:204-233-0
Product Categories:XYLOCAINE;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:118-08-1.mol
(-)-BETA-HYDRASTINE Structure
(-)-BETA-HYDRASTINE Chemical Properties
Melting point 132℃
alpha D20 -50° (c = 0.3 in abs alc)
Boiling point 510.32°C (rough estimate)
density 1.339±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 1.5614 (estimate)
storage temp. −20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml
form A crystalline solid
pka7.8(at 25℃)
color White to light yellow
Water Solubility 30mg/L(20 ºC)
CAS DataBase Reference118-08-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 36
RIDADR 1544
WGK Germany 3
RTECS MU6030000
HazardClass 6.1(b)
PackingGroup III
HS Code 2939800000
MSDS Information
ProviderLanguage
SigmaAldrich English
(-)-BETA-HYDRASTINE Usage And Synthesis
Description(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.
Usesanesthetic (local), antiarrhythmic
Uses(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.
DefinitionChEBI: A natural product found in Hydrastis canadensis.
References[1] SO KIM1. Effects of Hydrastine Derivatives on Dopamine Biosynthesis in PC12 Cells[J]. Planta medica, 2001, 67 1: 609-613. DOI: 10.1055/s-2001-17356
[2] SHOU YU YIN . Enantio-selective inhibition of (1R,9S)- and (1S,9R)-β-hydrastines on dopamine biosynthesis in PC12 cells[J]. Neuropharmacology, 2004, 47 7: Pages 1045-1052. DOI: 10.1016/j.neuropharm.2004.07.033
[3] SHOU YU YIN. Effects of (1R,9S)-beta-hydrastine on intracellular calcium concentration in PC12 cells.[J]. Biological & pharmaceutical bulletin, 2007, 30 8: 1547-1550. DOI: 10.1248/bpb.30.1547
[4] SHOU YU YIN. Inhibitory effects of (1R,9S)-β-hydrastine on calcium transport in PC12 cells[J]. Archives of Pharmacal Research, 2007, 30 1: 109-113. DOI: 10.1007/bf02977786
(-)-BETA-HYDRASTINE Preparation Products And Raw materials
Tag:(-)-BETA-HYDRASTINE(118-08-1) Related Product Information
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