H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH manufacturers
- NFAT Inhibitor
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- $68.00
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2026-07-21
- CAS:249537-73-3
- Purity: 99.00%
- Supply Ability: 10g
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| | H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH Basic information |
| | H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH Chemical Properties |
| Boiling point | 1982.4±65.0 °C(Predicted) | | density | 1.334±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: 15 mg/ml; Water: 10 mg/ml | | form | solid | | pka | 3.12±0.10(Predicted) | | color | White to off-white | | Water Solubility | Soluble to 2 mg/ml in water | | Sequence | H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH | | InChIKey | QPMHUXBSHGAVGD-MCDIZDEASA-N |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 2933299090 | | Storage Class | 11 - Combustible Solids |
| | H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH Usage And Synthesis |
| Description | NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. At 100 μM, this inhibitor effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways, unlike the immunosuppressants cyclosporin A and FK506 which indiscriminately block all calcineurin phosphatase activity. NFAT inhibitor can disrupt NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and can prevent the activation and proliferation of T cells both in vitro (~ 43% at 1 μM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice). | | Uses | NFAT Inhibitor, VIVIT has been used to study the signaling pathways involved in controlling inhibitory molecules and subsequent onset of T-cell impairment. | | Biochem/physiol Actions | High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells. | | storage | Store at -20°C | | References | [1] JOSE ARAMBURU. Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective Than Cyclosporin A[J]. Science, 1999, 285 5436. DOI: 10.1126/science.285.5436.2129
[2] MICHAEL H A ROEHRL. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 20: 7554-7559. DOI: 10.1073/pnas.0401835101
[3] HAIXIANG YU. Therapeutic potential of a synthetic peptide inhibitor of nuclear factor of activated T cells as antirestenotic agent.[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2006, 26 7: 1531-1537. DOI: 10.1161/01.atv.0000225286.30710.af
[4] XUEQIANG ZHAO. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression[J]. Nature Medicine, 2017, 23 3: 337-346. DOI: 10.1038/nm.4260 |
| | H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH Preparation Products And Raw materials |
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