Ethyl2-(4-hydroxypyrimidin-5-yl)acetate manufacturers
|
| | Ethyl2-(4-hydroxypyrimidin-5-yl)acetate Basic information |
| Product Name: | Ethyl2-(4-hydroxypyrimidin-5-yl)acetate | | Synonyms: | 4-Hydroxy-5-pyrimidineacetic acid ethyl ester;5-Pyrimidineaceticacid, 3,4-dihydro-4-oxo-, ethyl ester;ethyl 2-(6-oxo-1,6-dihydropyriMidin-5-yl)acetate;2-(6-oxo-1H-pyrimidin-5-yl)acetic acid ethyl ester;ethyl 2-(6-oxo-1H-pyrimidin-5-yl)acetate;ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE ISO 9001：2015 REACH;Ethyl2-(4-hydroxypyrimidin-5-yl)acetate | | CAS: | 6214-46-6 | | MF: | C8H10N2O3 | | MW: | 182.18 | | EINECS: | 604-604-1 | | Product Categories: | Heterocycle-Pyrimidine series | | Mol File: | 6214-46-6.mol |  |
| | Ethyl2-(4-hydroxypyrimidin-5-yl)acetate Chemical Properties |
| Melting point | 155-156 °C | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 8.62±0.40(Predicted) | | Appearance | White to off-white Solid |
| | Ethyl2-(4-hydroxypyrimidin-5-yl)acetate Usage And Synthesis |
| Synthesis | The ethanolic solution of sodium ethoxide was cooled to 0 °C under argon protection. Under continuous stirring, diethyl 2-formylsuccinate was slowly added. after 5 minutes, the corresponding formamidine acetate was added drop by drop while maintaining the condition of 0°C. Subsequently, the reaction mixture was warmed up to room temperature and stirred continuously for 3 days. After completion of the reaction, 5% aqueous hydrogen chloride solution was added and stirring was continued for 30 minutes. After addition of appropriate amount of water, ethanol was removed by distillation under reduced pressure at 30 °C. Finally, the precipitate was collected by filtration to afford the target product ethyl 4-hydroxy-5-pyrimidineacetate (Compound 1, where X = H, Me, Ph, SMe; Y = H, R1 = Et). | | References | [1] Monatshefte fur Chemie, 2016, vol. 147, # 4, p. 767 - 773 |
| | Ethyl2-(4-hydroxypyrimidin-5-yl)acetate Preparation Products And Raw materials |
|