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| | 7-methoxyindoline-2,3-dione Basic information | | Uses |
| Product Name: | 7-methoxyindoline-2,3-dione | | Synonyms: | 7-methoxyindoline-2,3-dione;7-Methoxy-1H-indole-2,3-dione;7-Methoxyindoline;1H-Indole-2,3-dione,7-Methoxy-;7-methoxyindoline 7-methoxyindoline-2,3-dione in stock Factory;ine-2,3-dione;7-METHOXY-1H-INDOLINE-2,3-DIONE | | CAS: | 84575-27-9 | | MF: | C9H7NO3 | | MW: | 177.16 | | EINECS: | | | Product Categories: | | | Mol File: | 84575-27-9.mol |  |
| | 7-methoxyindoline-2,3-dione Chemical Properties |
| Melting point | 240-242℃ | | density | 1.346 | | storage temp. | Sealed in dry,Room Temperature | | pka | 9.69±0.20(Predicted) | | Appearance | Reddish brown to red Solid |
| HazardClass | IRRITANT | | HS Code | 2933998090 |
| | 7-methoxyindoline-2,3-dione Usage And Synthesis |
| Uses | 7-Methoxy-1H-indole-2,3-dione is one of the key intermediates of the EP3 receptor, which has a variety of biological functions, including digestion, the nervous system, renal reabsorption, uterine contraction activity, and inhibition of gastric acid secretion. | | Synthesis | 7-Methoxyisatin is synthesized in four steps. a) 4-Hydroxybenzaldehyde reacts with methyl iodide in DMSO and K2CO3 to give 4-methoxybenzaldehyde. b) 4-Methoxybenzaldehyde reacts with methyl azidoacetate in sodium methoxide/methanol to yield an azide intermediate. This intermediate is refluxed in boiling xylene to give methyl 6-methoxyindole-2-carboxylate. c) This ester is saponified by refluxing with NaOH/methanol. Acidification yields 6-methoxyindole-2-carboxylic acid. d) This acid reacts with ethyl N,N-dichlorocarbamate in aqueous acetic acid. Work-up gives 7-methoxy-1H-indole-2,3-dione. |
| | 7-methoxyindoline-2,3-dione Preparation Products And Raw materials |
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