| Company Name: |
Ascent Scientific |
| Tel: |
4401179829988 |
| Email: |
customerservice@ascentscientific.co.uk |
DL-AP5 sodium salt manufacturers
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| | DL-AP5 sodium salt Basic information |
| Product Name: | DL-AP5 sodium salt | | Synonyms: | DL-AP5 sodium salt;DL-2-Amino-5-phosphonopentanoicacidsodiumsalt;DL-AP5.Na;2-AMINO-5-PHOSPHOVALERIC ACID SODIUM SALT;DL-AP-5 Sodium salt,DL AP5 Sodium salt,DLAP5 Sodium salt;Sodium2-amino-5-phosphonopentanoate;DL-AP5 sodium;DL-AP5 sodium salt, NMDA glutamate site antagonist | | CAS: | 1303993-72-7 | | MF: | C5H11NNaO5P | | MW: | 221.12 | | EINECS: | | | Product Categories: | Glutamate | | Mol File: | 1303993-72-7.mol |  |
| | DL-AP5 sodium salt Chemical Properties |
| Melting point | >142oC (dec.) | | storage temp. | Store at RT | | solubility | Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly), Water (Slightly) | | form | Solid | | color | White to Off-White | | Water Solubility | Soluble to 100 mM in water | | Stability: | Hygroscopic |
| | DL-AP5 sodium salt Usage And Synthesis |
| Uses | DL-AP5 is a potent NMDA antagonist (1). | | in vivo | DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin[4]. | Animal Model: | Male Wistar rats (180-230 g)[3] | | Dosage: | 1, 3.2 and 10 μg/rat | | Administration: | Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once | | Result: | Significantly decreased the effect of NMDA (10-2 μg/rat, intra-CA1) with significant interaction. |
| Animal Model: | Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4] | | Dosage: | 0, 2.5, 5, and 10 nmol; in a volume of 10 μL | | Administration: | Intracerebroventricular injection | | Result: | Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses. |
| Animal Model: | Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4] | | Dosage: | 5 nmol | | Administration: | Intracerebroventricular injection, followed by ghrelin (0.6 nmol) | | Result: | Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin. |
| | IC 50 | NMDA Receptor | | storage | Room temperature (desiccate) |
| | DL-AP5 sodium salt Preparation Products And Raw materials |
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