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| | 3,3-Difluorocyclopentanamine hydrochloride Basic information |
| Product Name: | 3,3-Difluorocyclopentanamine hydrochloride | | Synonyms: | 3,3-difluorocyclopentan-1-aMine;3,3-difluorocyclopentanaMine HCl;3,3-difluorocyclopentan-1-amine hydrochloride;3,3-Difluorocyclopentanamine hydrochloride - D7892;1. 3,3-Difluorocyclopentanamine hydrochloride;3,3-Difluoro-cyclopentylamine hydrochloride;3,3-DIFLUOROCYCLOPENTANAMINE HYDROCHLORIDE;Guanosine, 8-([1,1′-biphenyl]-4-ylamino)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-N-[(dimethylamino)methylene]-6-O-(phenylmethyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] (ACI) | | CAS: | 939398-48-8 | | MF: | C5H10ClF2N | | MW: | 157.59 | | EINECS: | | | Product Categories: | | | Mol File: | 939398-48-8.mol |  |
| | 3,3-Difluorocyclopentanamine hydrochloride Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | White to off-white Solid | | InChI | InChI=1S/C5H9F2N.ClH/c6-5(7)2-1-4(8)3-5;/h4H,1-3,8H2;1H | | InChIKey | IIUHMNFTPGBLCX-UHFFFAOYSA-N | | SMILES | FC1(CCC(N)C1)F.Cl |
| | 3,3-Difluorocyclopentanamine hydrochloride Usage And Synthesis |
| Synthesis | Benzyl 3N-difluorocyclopentylcarbamate (1.5 g, 5.88 mmol) was used as a raw material, which was dissolved in 6N HCl (6 mL) and the reaction was heated at 100 °C for 20 hours. After completion of the reaction, the mixture was cooled to room temperature and the brown solution was extracted with ether (2 x 2 mL) to remove unreacted feedstock and toluene. The aqueous phase was dried over vacuum heat to afford 3,3-difluorocyclopentylamine hydrochloride as a light brown solid (0.79 g, 85% yield). The structure of the product was confirmed by the following characterization data: 1H NMR (MeOD-d4, 400 MHz) δ: 4.79 (m, 1H), 2.62 (m, 1H), 2.32 (m, 2H), 2.18 (m, 2H), 1.87 (m, 1H); 13C NMR (MeOD-d4, 400 MHz) δ: 131.4 (t), 41.0 (t), 34.8 (t), 28.9; 19F NMR (MeOD-d4, standard CFCl3, 400 MHz) δ: -93.0 (m, 2F).LC/MS analysis showed the [M + H]+ peak was located at 121.9. | | References | [1] Patent: WO2013/107405, 2013, A1. Location in patent: Page/Page column 45
[2] Patent: US2015/87600, 2015, A1. Location in patent: Page/Page column
[3] Patent: US2007/161685, 2007, A1. Location in patent: Page/Page column 118-119 |
| | 3,3-Difluorocyclopentanamine hydrochloride Preparation Products And Raw materials |
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