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| | 4-(alpha-Methylbenzyl)resorcinol Basic information |
| | 4-(alpha-Methylbenzyl)resorcinol Chemical Properties |
| Melting point | 78-79℃ | | Boiling point | 244°C/12mmHg(lit.) | | density | 1.171 | | vapor pressure | 0Pa at 20℃ | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) | | form | Solid | | pka | 9.77±0.40(Predicted) | | color | Light Beige to Pale Brown | | Water Solubility | 3.85g/L at 20℃ | | InChI | InChI=1S/C14H14O2/c1-10(11-5-3-2-4-6-11)13-8-7-12(15)9-14(13)16/h2-10,15-16H,1H3 | | InChIKey | PQSXNIMHIHYFEE-UHFFFAOYSA-N | | SMILES | C1(O)=CC=C(C(C2=CC=CC=C2)C)C(O)=C1 | | LogP | 2.11 at 22℃ |
| | 4-(alpha-Methylbenzyl)resorcinol Usage And Synthesis |
| Uses | 4-(1-Phenylethyl)-1,3-benzenediol is an novel active ingredient of highly efficient skin lightening agents. | | Flammability and Explosibility | Non flammable | | Synthesis | 1) Under nitrogen protection, 231 g (2.1 mol) of resorcinol, 4.62 g of the solid acid H2SO4-SiO2, and 220 mL of toluene were added to a reactor, heated to 95 °C, and maintained at that temperature. Subsequently, 104 g (1 mol) of styrene was slowly added dropwise to the reactor at a controlled rate for 1 hour. After completion of the dropwise addition, the reaction was continued at 95 °C for 1 h to obtain the reaction mixture. 2) After completion of the reaction, the reaction mixture was filtered to remove the solid acid H2SO4-SiO2. 150 mL of 0.5% aqueous sodium bicarbonate was added to the filtrate for extraction to separate the organic phase. The organic phase was washed twice more (150 mL each) with deionized water. The organic phase was collected and toluene was removed by rotary evaporator. Subsequently, 250 mL of a mixed solution of hexane and toluene (1:5, v/v) was added for recrystallization, and 177.6 g of white crystal product was obtained in 83% yield. | | References | [1] Patent: CN105237359, 2016, A. Location in patent: Paragraph 0038; 0039; 0040; 0041; 0042; 0043; 0044
[2] DRP/DRBP Org.Chem.,
[3] Journal of Organic Chemistry, 1952, vol. 17, p. 243,247
[4] Bulletin of the Chemical Society of Japan, 1995, vol. 68, # 10, p. 2955 - 2960
[5] DRP/DRBP Org.Chem., |
| | 4-(alpha-Methylbenzyl)resorcinol Preparation Products And Raw materials |
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