4-(2H-Tetrazol-5-yl)-phenylamine

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4-(2H-Tetrazol-5-yl)-phenylamine Basic information
Product Name:4-(2H-Tetrazol-5-yl)-phenylamine
Synonyms:5-(4-Aminophenyl)-1H-tetrazole;Albb-005577;5-(4-AMinophenyl)-1H-tetr...;5-(4-AMino-phenyl)-2H-tetrazol;4-(2H-1,2,3,4-tetrazol-5-yl)aniline;BUTTPARK 32\02-01;4-(5-Tetrazolyl)aniline;4-(1H-Tetrazol-5-yl)aniline, 97%
CAS:46047-18-1
MF:C7H7N5
MW:161.16
EINECS:
Product Categories:
Mol File:46047-18-1.mol
4-(2H-Tetrazol-5-yl)-phenylamine Structure
4-(2H-Tetrazol-5-yl)-phenylamine Chemical Properties
Melting point 265°C
Boiling point 418.8±47.0 °C(Predicted)
density 1.401±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka5.49±0.10(Predicted)
AppearanceYellow to brown Solid
Water Solubility Slightly soluble in water.
Safety Information
HazardClass IRRITANT
MSDS Information
4-(2H-Tetrazol-5-yl)-phenylamine Usage And Synthesis
UsesUsed to prepare dyes. Industrially used in natural gas and refinery process streams. They also are used in polymer industry as monomers. Amines find use as additives for lubricating oils, engine fuels, and asphalt, and are producers of ethanolamines.
Synthesis
5-(4-NITRO-PHENYL)-2H-TETRAZOLE

16687-60-8

4-(2H-TETRAZOL-5-YL)-PHENYLAMINE

46047-18-1

General procedure for the synthesis of 5-(4-aminophenyl)-2H-tetrazole from 5-(4-nitrophenyl)-1H-tetrazole: 5-(4-nitrophenyl)-1H-tetrazole (5.3 g, 27.7 mmol), anhydrous ethanol (50 mL), ethyl acetate (50 mL), and 10% palladium-carbon-caprolactone catalyst (500 mg) were added to an autoclave reactor, and reacted under hydrogen atmosphere ( 30 psi) for 16 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed with ethyl acetate. The filtrate was concentrated under reduced pressure to afford 4-(1H-tetrazol-5-yl)aniline as a light orange solid (4.5 g, 100% yield).

References[1] Patent: WO2006/15158, 2006, A1. Location in patent: Page/Page column 38
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 17, p. 7392 - 7416
[3] Patent: WO2012/135641, 2012, A2. Location in patent: Page/Page column 67
[4] Patent: US6043254, 2000, A
[5] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1981, vol. 17, # 11, p. 1142 - 1144
4-(2H-Tetrazol-5-yl)-phenylamine Preparation Products And Raw materials
Raw materials4-Aminobenzonitrile-->5-(4-Nitro-phenyl)-2H-tetrazole-->Ethyl acetate-->Hydrogen-->Ethanol
Preparation Products4-(2-methyl-2H-tetrazol-5-yl)aniline(SALTDATA: FREE)
Tag:4-(2H-Tetrazol-5-yl)-phenylamine(46047-18-1) Related Product Information
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