| Company Name: |
Sigma-Aldrich |
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
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| | Anti-TDP-43 Basic information |
| Product Name: | Anti-TDP-43 | | Synonyms: | Anti-TARDBP (ab2) antibody produced in rabbit;Anti-TARDBP (ab1) antibody produced in rabbit;Anti-TAR DNA binding protein;Anti-TDP-43 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Anti-TDP-43 Structure]() |
| | Anti-TDP-43 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | rabbit |
| WGK Germany | WGK 1 | | Storage Class | 10 - Combustible liquids |
| | Anti-TDP-43 Usage And Synthesis |
| Uses | Anti-TARDBP (AB1) polyclonal antibody is used to tag TAR DNA binding protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of TAR DNA binding protein in the repression of gene expression and regulation of pre-mRNA splicing and translation. | | Biological Activity | HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome th at produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator T at is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor th at binds to chromosomally integrated TAR DNA and represses HIV-1 transcription.HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome th at produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator T at is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor th at binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. |
| | Anti-TDP-43 Preparation Products And Raw materials |
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