- 4-Azido-L-phenylalanine
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- $0.00 / 250mg
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2025-06-07
- CAS:33173-53-4
- Min. Order: 250mg
- Purity: >95.00%
- Supply Ability: 250mg
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| | 4-Azido-L-phenylalanine Basic information |
| Product Name: | 4-Azido-L-phenylalanine | | Synonyms: | 4-AZIDO-L-PHENYLALANINE;4-Azido-L-phenylalanine≥ 98% (HPLC);L-Phe(4-azido)-OH;p-Azido-L-phenylalanine;P-AZIDO-PHENYLALANINE;4-azidophenylalanine;L-Phenylalanine, 4-azido-;(S)-2-aMino-3-(4-azidophenyl)propanoic acid | | CAS: | 33173-53-4 | | MF: | C9H10N4O2 | | MW: | 206.21 | | EINECS: | | | Product Categories: | | | Mol File: | 33173-53-4.mol |  |
| | 4-Azido-L-phenylalanine Chemical Properties |
| storage temp. | -20°C | | solubility | Water : 6.2 mg/mL (30.07 mM; ultrasonic and adjust pH to 6 with HCl);DMSO : 6 mg/mL (29.10 mM; ultrasonic and adjust pH to 6 with HCl) | | form | Solid | | color | White to yellow | | Appearance | off-white solid | | InChI | InChI=1/C9H10N4O2/c10-8(9(14)15)5-6-1-3-7(4-2-6)12-13-11/h1-4,8H,5,10H2,(H,14,15)/t8-/s3 | | InChIKey | NEMHIKRLROONTL-SBYBRXNCNA-N | | SMILES | C(C1C=CC(N=[N+]=[N-])=CC=1)[C@H](N)C(=O)O |&1:10,r| |
| WGK Germany | WGK 3 | | HS Code | 2922498590 | | Storage Class | 5.2 - Organic peroxides and self-reacting hazardous materials | | Hazard Classifications | Self-react. C |
| | 4-Azido-L-phenylalanine Usage And Synthesis |
| Description | 4-Azido-L-phenylalanine (4AZP) is an unnatural amino acid analog of L-phenylalanine that contains an azide moiety. 4AZP-labeling is a fast, sensitive, and non-radioactive alternative to the traditional technique for detecting nascent protein synthesis.
4AZP is randomly incorporated into synthesizing protein instead of phenylalanine during translation. The resulting azide-labeled full-length proteins can be detected via copper-catalyzed click reaction (with fluorescent or biotin-labeled alkynes) or copper-free click reaction (with cycloalkynes) and used for subsequent microscopic imaging or purification tasks. | | Chemical Properties | Off-white to brown powder | | Uses | 4-Azido-L-phenylalanine is an unnatural derivative of L-phenylalanine. It is a nonpolar, essential amino acid that naturally occurs in the human body and is also used to treat patients with depression. | | Uses | The in-vivo incorporation of clickable unnatural amino acids such as 4-Azido-L-phenylalanine with unique reactivity at a defined postition is used for functionalization of proteins. The azide functionalities in the protein can then be modified with almost any alkyne bearing molecule by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). Copper-free alternatives with strained internal alkynes are also available (SPAAC). Some examples enabled with this technique are protein PEGylation, masking with sugars, and the attachment to antibodies. | | reaction suitability | reaction type: click chemistry
reaction type: solution phase peptide synthesis |
| | 4-Azido-L-phenylalanine Preparation Products And Raw materials |
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