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BOC Sciences |
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CXCR3 Antagonist 6c manufacturers
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| | CXCR3 Antagonist 6c Basic information |
| Product Name: | CXCR3 Antagonist 6c | | Synonyms: | CXCR3 Antagonist 6c;1H-1,4-Diazepine-1-carboxamide, 4-[2-[(3-chlorobenzoyl)amino]-4-[[[2-(2,4-dichlorophenyl)ethyl]amino]carbonyl]phenyl]-N-ethylhexahydro-;CXCR3 Antagonist 6c,CXCR-3 Antagonist 6c;CXCR3Antagonist6c-Compound6c;4-(2-(3-chlorobenzamido)-4-((2,4-dichlorophenethyl)carbamoyl)phenyl)-N-ethyl-1,4-diazepane-1-carboxamide;CXCR3 antagonist 1 | | CAS: | 870998-13-3 | | MF: | C30H32Cl3N5O3 | | MW: | 616.97 | | EINECS: | | | Product Categories: | | | Mol File: | 870998-13-3.mol |  |
| | CXCR3 Antagonist 6c Chemical Properties |
| Boiling point | 768.6±60.0 °C(Predicted) | | density | 1.343±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: >100mM | | form | A crystalline solid | | pka | 12.42±0.70(Predicted) | | color | White to off-white |
| | CXCR3 Antagonist 6c Usage And Synthesis |
| Uses | CXCR3 antagonist 1 (compound 6c) is a selective and non-cytotoxic CXCR3 antagonist (IC50=0.06 μM). CXCR3 antagonist 1 has potential in researching inflammatory diseases (including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes)[1]. | | IC 50 | CXCR3: 0.06 μM (IC50) | | References | [1] Cole A G, et al. Identification and initial evaluation of 4-N-aryl-[1, 4] diazepane ureas as potent CXCR3 antagonists. Bioorganic Med. Chem Lett. 2006 Jan;16(1):200-203. |
| | CXCR3 Antagonist 6c Preparation Products And Raw materials |
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