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LIMK1 inhibitor BMS 4 manufacturers
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| | LIMK1 inhibitor BMS 4 Basic information |
| Product Name: | LIMK1 inhibitor BMS 4 | | Synonyms: | LIMK1 inhibitor BMS 4 - BMS 4;1-ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]urea;LIMK1 inhibitor BMS 4;Urea, N-ethyl-N'-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-(2-pyrazinyl)-4-pyrimidinyl]-2-thiazolyl]- | | CAS: | 905298-84-2 | | MF: | C23H23N7O2S | | MW: | 461.54 | | EINECS: | | | Product Categories: | | | Mol File: | 905298-84-2.mol |  |
| | LIMK1 inhibitor BMS 4 Chemical Properties |
| Melting point | 274-276 °C | | density | 1.297±0.06 g/cm3(Predicted) | | pka | 8.63±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | LIMK1 inhibitor BMS 4 Usage And Synthesis |
| Uses | LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2]. | | IC 50 | LIMK1: 7.25 (pIC50); LIMK2: 6.87 (pIC50) | | References | [1] Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65(20):13705-13713. DOI:10.1021/acs.jmedchem.2c00751
[2] Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8. DOI:10.1158/1535-7163.MCT-08-0826 |
| | LIMK1 inhibitor BMS 4 Preparation Products And Raw materials |
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