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| | 8-Hydroxy-6-quinolinecarboxylic acid Basic information |
| Product Name: | 8-Hydroxy-6-quinolinecarboxylic acid | | Synonyms: | 8-Hydroxy-6-quinolinecarboxylic acid;8-Hydroxyquinoline-6-carboxylic acid;6-Quinolinecarboxylic acid, 8-hydroxy-;1,4-Benzenedicarbonitrile,2,10-dibromo-;1H-Benzimidazole-1-carboxylicacid,2,3-dihydro-7-oxo-,ethylester;3-Oxetanol,6-ethynyl-;8-Hydroxy-6-quinolinecarboxylic aci;Moxifloxacin Impurity 231 | | CAS: | 90800-42-3 | | MF: | C10H7NO3 | | MW: | 189.17 | | EINECS: | | | Product Categories: | | | Mol File: | 90800-42-3.mol |  |
| | 8-Hydroxy-6-quinolinecarboxylic acid Chemical Properties |
| Melting point | 284 °C(Solv: acetic acid (64-19-7)) | | Boiling point | 431.7±35.0 °C(Predicted) | | density | 1.480±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.93±0.30(Predicted) |
| | 8-Hydroxy-6-quinolinecarboxylic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 8-hydroxyquinoline-6-carboxylic acid from 4-amino-3-hydroxybenzoic acid and acrolein [stabilized]: acrolein (21.8 mL, 326 mmol) was added slowly and dropwise to an aqueous 12 N solution (50 mL) containing 4-amino-3-hydroxybenzoic acid (5.00 g, 33.0 mmol). The reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The resulting residue was purified by reversed-phase chromatography (elution gradient: water:CH3CN 100:0 to 50:50), resulting in the target product 8-hydroxyquinoline-6-carboxylic acid (561 mg, 9% yield). The product was analyzed by UPLC/MS (ES+) and showed m/z 190.04 [M+H]+. | | References | [1] Journal of Medicinal Chemistry, 2013, vol. 56, # 2, p. 521 - 533
[2] Patent: WO2015/26792, 2015, A1. Location in patent: Paragraph 0421 |
| | 8-Hydroxy-6-quinolinecarboxylic acid Preparation Products And Raw materials |
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