- Methyl 3-oxovalerate
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- $10.00
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2026-09-13
- CAS:30414-53-0
- Min. Order: 1ASSAYS
- Purity: 99%
- Supply Ability: 1 ton
- Methyl 3-oxovalerate
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-
2026-09-11
- CAS:30414-53-0
- Min. Order: 1KG
- Purity: 99%min
- Supply Ability: 10 TONS
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| | Methyl 3-oxovalerate Basic information |
| Product Name: | Methyl 3-oxovalerate | | Synonyms: | PROPIONYLACETIC ACID METHYL ESTER;Methy3-oxo-valerate;Methyl 3-oxo-n-valerate;Methyl beta-ketovalerate;methyl3-0xopentanoate;Valeric acid, 3-oxo-, methyl ester;3-oxo-methylvalerate;3-oxovaL | | CAS: | 30414-53-0 | | MF: | C6H10O3 | | MW: | 130.14 | | EINECS: | 250-184-3 | | Product Categories: | straight chain compounds | | Mol File: | 30414-53-0.mol |  |
| | Methyl 3-oxovalerate Chemical Properties |
| Melting point | -35 °C | | Boiling point | 73-74 °C5 mm Hg(lit.) | | density | 1.037 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.422(lit.) | | Fp | 71 °C | | storage temp. | Store below +30°C. | | solubility | Chloroform | | pka | 10.56±0.46(Predicted) | | form | Liquid | | Specific Gravity | 1.05 | | color | Clear colorless to slightly yellow | | Water Solubility | SLIGHTLY SOLUBLE | | BRN | 1753684 | | InChIKey | XJMIXEAZMCTAGH-UHFFFAOYSA-N | | CAS DataBase Reference | 30414-53-0(CAS DataBase Reference) | | NIST Chemistry Reference | Pentanoic acid, 3-oxo-, methyl ester(30414-53-0) |
| Hazard Codes | F,Xi | | Risk Statements | 36/37/38 | | Safety Statements | 24/25-36-26 | | WGK Germany | 3 | | Hazard Note | Flammable | | HazardClass | IRRITANT | | HS Code | 29183000 |
| | Methyl 3-oxovalerate Usage And Synthesis |
| Chemical Properties | clear colorless to slightly yellow liquid | | Uses | Methyl 3-oxovalerate is used in the synthesis of anti-Perol stereospecific reductases that can be used in the asymmettric and environmentally friendly reduction of ketones. | | Uses | Methyl Propionylacetate is used in the synthesis of anti-Perol stereospecific reductases that can be used in the asymmettric and environmentally friendly reduction of ketones. | | Synthesis Reference(s) | Journal of the American Chemical Society, 92, p. 6702, 1970 DOI: 10.1021/ja00725a088
The Journal of Organic Chemistry, 43, p. 2087, 1978 DOI: 10.1021/jo00404a066 | | Synthesis | The general procedure for synthesizing methyl 3-oxovalerate from propionyl chloride was as follows: in a mixed solvent of 520 mL of methylene chloride and 30 mL of methyl ethyl ketone, 116 g (1.0 mol) of methyl acetoacetate, 77.8 g (1.05 mol) of calcium hydroxide, and 106.5 g (1.15 mol) of propionyl chloride were added, and the reaction conditions were the same as those in Example 1. After completion of the reaction, the pH of the reaction mixture was adjusted with ammonia to 9.1. 117 g of methyl 3-oxovalerate was finally obtained, which was analyzed by gas chromatography (GC) with a purity of 79.0% and a yield of 71.0%. | | References | [1] Patent: US5194671, 1993, A |
| | Methyl 3-oxovalerate Preparation Products And Raw materials |
| Raw materials | Ammonium hydroxide-->Ammonium chloride-->Methyl acetoacetate-->2-Pentenoic acid, 3-amino-, methyl ester, (2Z)--->Hexanoicacid, 2,4-dioxo-, methyl ester-->Methyl malonyl chloride-->3-OxopentanoicAcid-->5-(1-hydroxypropylidene)-2,2-diMethyl-1,3-dioxane-4,6-dione-->Methyl 2-pentynoate-->ethylmagnesium iodide-->2,2-diMethyl-5-propanoyl-1,3-dioxane-4,6-dione-->Potassium 3-methoxy-3-oxopropanoate-->Methyl cyanoacetate-->2-Butanone | | Preparation Products | 2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)acetic acid-->4-Ethyl-6-hydroxy-2-methylpyrimidine-->2-(2,5-Dimethyl-1,3-thiazol-4-yl)acetic acid-->Methyl 2-(2,5-dimethyl-1,3-thiazol-4-yl)acetate-->Methyl 4-bromo-3-oxopentanoate-->2-Ethyl-4-methylquinoline-3-carboxylic acid-->TAK-441-->methyl 3-oxohept-6-ynoate |
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