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[D-PRO2, D-TRP7,9]-SUBSTANCE P

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CAS:80434-86-2
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Products Intro: Product Name:(D-Pro2,D-Trp79)-Substance P
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[D-PRO2, D-TRP7,9]-SUBSTANCE P Basic information
Product Name:[D-PRO2, D-TRP7,9]-SUBSTANCE P
Synonyms:dt79;ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2;ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 3HCL 6H2O;ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 HYDROCHLORIDE;[D-PRO2, D-TRP7,9]-SUBSTANCE P;[D-PRO2,D-TRP7,9]-SUBSTANCE P 3HCL 6H2O;[D-PRO2,D-TRP7,9]-SUBSTANCE P HYDROCHLORIDE;(D-pro2
CAS:80434-86-2
MF:C74H106N20O13S
MW:1515.83
EINECS:
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Mol File:80434-86-2.mol
[D-PRO2, D-TRP7,9]-SUBSTANCE P Structure
[D-PRO2, D-TRP7,9]-SUBSTANCE P Chemical Properties
density 1.452±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. −20°C
pka13.270±0.46(predicted)
Safety Information
WGK Germany 3
MSDS Information
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SigmaAldrich English
[D-PRO2, D-TRP7,9]-SUBSTANCE P Usage And Synthesis
Uses[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2].
in vivo

[D-Pro2,D-Trp7,9] Substance P (0-30 nmol, Intravitreal injection) greatly reduces not only the effects of exogenous Substance P (HY-P0201) but also the inflammatory response to trauma to the eye[1].
[D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli[2].

Animal Model:Adult pigmented rabbits (1.5-3 kg)[1]
Dosage:0.03, 0.3, 3, and 30 nmol
Administration:Intravitreal injection or topical application onto the eye, 60 μL
Result:Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye.
References[1] Holmdahl G, et al. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Science. 1981 Nov 27;214(4524):1029-31. DOI:10.1126/science.6171036
[2] Hkanson R, et al. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Br J Pharmacol. 1982 Dec;77(4):697-700. DOI:10.1111/j.1476-5381.1982.tb09348.x
[3] Matalińska J, et al. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells. Folia Neuropathol. 2020;58(3):237-244. English. DOI:10.5114/fn.2020.100066
[D-PRO2, D-TRP7,9]-SUBSTANCE P Preparation Products And Raw materials
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