D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2

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Company Name:	Hangzhou Peptidego Biotech Co.,Ltd.
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D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2 Basic information

Product Name:	D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2
Synonyms:	pro(4)-trp(7,9)-substancep(4-11;(D-PRO4,D-TRP7,9)-SUBSTANCE P (4-11);[D-PRO4,D-TRP7,9]-SUBSTANCE P (4-11) ACOH 4H2O;D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 ACOH 4H2O;H-D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2;substance P (4-11), Pro(4)-Trp(7,9)-;Substance P, [D-Pro4, D-Trp7,9];D-Pro-L-Glu(NH2)-L-Glu(NH2)-D-Trp-L-Phe-D-Trp-L-Leu-L-Met-NH2
CAS:	81039-85-2
MF:	C57H75N13O10S
MW:	1134.35
EINECS:
Product Categories:
Mol File:	81039-85-2.mol

D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2 Chemical Properties

Safety Information

MSDS Information

D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2 Usage And Synthesis

Uses	[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1].
in vivo	[D-Pro4,D-Trp7,9] Substance P (4-11) inhibits the hypotensive effect of Substance P in anesthetized rats, the vasodilator effect in the rabbit perfused heart, relaxation induced by Substance P in dog carotid arteries contracted with noradrenaline, and stimulatory actions of Substance P in the guinea pig ileum and the guinea pig trachea^[1]. [D-Pro4,D-Trp7,9] Substance P (4-11) (0.3 nM/K/min; i.p. for 7 days) significantly decreases plasma aldosterone (ALDO) concentration and causes atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells^[2].
References	[1] Mizrahi J, et al. Substance P antagonists active in vitro and in vivo. Eur J Pharmacol. 1982 Aug 13;82(1-2):101-5. DOI:10.1016/0014-2999(82)90561-1 [2] Mazzocchi G, et al. Evidence that endogenous substance-P (SP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Neuropeptides. 1995 Jul;29(1):53-8. DOI:10.1016/0143-4179(95)90056-x

D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2 Preparation Products And Raw materials

Tag:D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2(81039-85-2) Related Product Information

D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Nle-NH2 D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2 Arg-D-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2 acetate salt 2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-carbaldehyde Substance P (4-11) H-ARG-D-TRP-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2,ARG-D-TRP-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 [D-PRO2, D-TRP7,9]-SUBSTANCE P D-Prolinamide