| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
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| | LX-2761 Basic information |
| Product Name: | LX-2761 | | Synonyms: | LX-2761;N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide;N-(1-((2-(DIMETHYLAMINO)ETHYL)AMINO)-2-METHYL-1-OXOPROPAN-2-YL)-4-(4-(2-METHYL-5-((2S,3R,4R,5S,6R)-3;LX2761; LX-2761; LX 2761;1610954-97-6;Benzenebutanamide, N-[2-[[2-(dimethylamino)ethyl]amino]-1,1-dimethyl-2-oxoethyl]-4-[[2-methyl-5-[(5R)-5-C-(methylthio)-β-D-xylopyranosyl]phenyl]methyl]-;LX-2761,LX2761;N-(1-((2-(Dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-(3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran -2-yl)benzyl)phenyl)butanamide | | CAS: | 1610954-97-6 | | MF: | C32H47N3O6S | | MW: | 601.8 | | EINECS: | | | Product Categories: | | | Mol File: | 1610954-97-6.mol |  |
| | LX-2761 Chemical Properties |
| Boiling point | 843.9±65.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 12.95±0.70(Predicted) |
| | LX-2761 Usage And Synthesis |
| Uses | LX2761 is chemically stable and potent inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 in vitro with IC50s of 2.2 nM and 2.7nM for hSGLT1 and hSGLT2, but displays specific SGLT1 inhibition in the gastrointestinal (GI) tract[1]. | | IC 50 | SGLT1; SGLT2 | | References | [1] Goodwin NC, et al. Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restrictedto the Intestinal Lumen, for the Treatment of Diabetes. J Med Chem. 2017 Jan 26;60(2):710-721. DOI:10.1021/acs.jmedchem.6b01541 |
| | LX-2761 Preparation Products And Raw materials |
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