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Bromo-PEG3-CH2CO2tBu manufacturers
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| | Bromo-PEG3-CH2CO2tBu Basic information |
| Product Name: | Bromo-PEG3-CH2CO2tBu | | Synonyms: | Bromo-PEG3-CH2CO2tBu;Br-PEG3-CH2COOtBu;Bromo-PEG3-CH2-Boc;t-butyl acetate-PEG3-bromide
BROMO-PEG3-CH2CO2TBU;Acetic acid, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester;Br-PEG3-CH2COOtBu/Acetic acid, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester;Br-PEG3-CH2-Boc;CH2COOH t-Bu Ester-PEG3-Bromide | | CAS: | 2100306-71-4 | | MF: | C12H23BrO5 | | MW: | 327.21 | | EINECS: | | | Product Categories: | | | Mol File: | 2100306-71-4.mol |  |
| | Bromo-PEG3-CH2CO2tBu Chemical Properties |
| Boiling point | 360.9±27.0 °C(Predicted) | | density | 1.246±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | Soluble in DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow |
| | Bromo-PEG3-CH2CO2tBu Usage And Synthesis |
| Description | Bromo-PEG3-CH2CO2tBu is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Bromo-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Bromo-PEG3-CH2CO2tBu Preparation Products And Raw materials |
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