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| | Br-PEG3-CH2CO2H Basic information |
| Product Name: | Br-PEG3-CH2CO2H | | Synonyms: | Br-PEG3-CH2CO2H;Bromo-PEG3-CH2CO2H;Br-PEG3-CH2COOH;Acetic acid, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-;Br-PEG3-CH2COOH/Acetic acid, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-;2-(2-(2-(2-Bromoethoxy)ethoxy)ethoxy)acetic acid;Bromo-PEG3-CH2COOH | | CAS: | 1346502-15-5 | | MF: | C8H15BrO5 | | MW: | 271.11 | | EINECS: | | | Product Categories: | | | Mol File: | 1346502-15-5.mol |  |
| | Br-PEG3-CH2CO2H Chemical Properties |
| Boiling point | 379.7±27.0 °C(Predicted) | | density | 1.446±0.06 g/cm3(Predicted) | | pka | 3.39±0.10(Predicted) |
| | Br-PEG3-CH2CO2H Usage And Synthesis |
| Description | Bromo-PEG3-CH2CO2H is a PEG linker containing a bromide group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. | | Uses | Br-PEG3-CH2COOH (compound 28) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. | | IC 50 | PEGs | | References | [1] Zha Z, et al. Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA). J Med Chem. 2011 Dec 8;54(23):8085-98. DOI:10.1021/jm2009106 |
| | Br-PEG3-CH2CO2H Preparation Products And Raw materials |
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