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| | N-Boc-Azido-tris(ethylenoxy)-L-alanin Basic information |
| Product Name: | N-Boc-Azido-tris(ethylenoxy)-L-alanin | | Synonyms: | N-Boc-Azido-tris(ethylenoxy)-L-alanin;Azido-PEG3-Ala-Boc;Boc-D-3-(N3-PEG3)-Ala-OH;O-(N3-PEG2-CH2CH2)-Boc-D-serine;5,8,11-Trioxa-2-azatridecanoic acid, 13-azido-3-carboxy-, 1-(1,1-dimethylethyl) ester, (3R)- | | CAS: | 2054345-68-3 | | MF: | C14H26N4O7 | | MW: | 362.38 | | EINECS: | | | Product Categories: | | | Mol File: | 2054345-68-3.mol |  |
| | N-Boc-Azido-tris(ethylenoxy)-L-alanin Chemical Properties |
| | N-Boc-Azido-tris(ethylenoxy)-L-alanin Usage And Synthesis |
| Description | N-Boc-Azido-tris(ethylenoxy)-L-alanin has a Boc protected L-alanine residue and an azido group. The Boc protecting group can be removed under acidic conditions. The azide can react with alkynes, DBCO and BCN under copper-catalyzed Click Chemistry reactions. | | Uses | Azido-PEG3-Ala-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-Ala-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-Boc-Azido-tris(ethylenoxy)-L-alanin Preparation Products And Raw materials |
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