Azide-PEG3-L-alanine-Fmoc

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Azide-PEG3-L-alanine-Fmoc Basic information
Product Name:Azide-PEG3-L-alanine-Fmoc
Synonyms:Azide-PEG3-L-alanine-Fmoc;N-Fmoc-Azido-tris(ethylenoxy)-L-alanine;O-(N3-PEG2-CH2CH2)-Fmoc-D-serine
CAS:2054345-69-4
MF:C24H28N4O7
MW:484.51
EINECS:
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Mol File:2054345-69-4.mol
Azide-PEG3-L-alanine-Fmoc Structure
Azide-PEG3-L-alanine-Fmoc Chemical Properties
Safety Information
MSDS Information
Azide-PEG3-L-alanine-Fmoc Usage And Synthesis
DescriptionN-Fmoc-Azido-tris(ethylenoxy)-L-alanine has an Fmoc protected L-alanine residue and a terminal azide moiety. The Fmoc protecting group can be removed under basic conditions to be further reacted. The azide can react with alkynes under copper-catalyzed Click Chemistry reactions.
UsesAzide-PEG3-L-alanine-Fmoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-L-alanine-Fmoc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azide-PEG3-L-alanine-Fmoc Preparation Products And Raw materials
Tag:Azide-PEG3-L-alanine-Fmoc(2054345-69-4) Related Product Information
Fmoc-Ser(n-Bu)-OH (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-propoxypropanoic acid N-Boc-Azido-tris(ethylenoxy)-L-alanin azido-tris(ethylenoxy)-L-alanine TFA Salt 13-zido-,,1-rioxa--zatridecanoic acid 9H-luoren--lmethyl ester Fmoc-N-amido-PEG5-azide