Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2

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Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 Basic information
Product Name:Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2
Synonyms:(d-phe(sup2))-(d-ala(sup6))-lhrh;(d-phe(sup2))-(d-ala(sup6))-luteinizinghormone-releasinghormon;(d-phe(sup2))-(d-ala(sup6))-luteinizinghormone-releasinghormone;2-d-phenylalanine-6-d-alanine-luteinizinghormone-releasinghormone(pig;wy-18,185;D-phe2,D-ala6-luteinizing hormone*releasing hormo;D-PHE2 D-ALA6-LUTEINIZING HORMONE &;LHRH, Phe(2)-Ala(6)-
CAS:54784-44-0
MF:C59H79N15O13
MW:1206.35
EINECS:
Product Categories:
Mol File:54784-44-0.mol
Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 Structure
Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 Chemical Properties
storage temp. −20°C
Safety Information
Hazard Codes T
Risk Statements 60
Safety Statements 53-22-36/37/39-45
WGK Germany 3
RTECS OK6600000
MSDS Information
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SigmaAldrich English
Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 Usage And Synthesis
Uses[D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities[1].
in vivo

[D-Phe2,D-Ala6]-LH-RH inhibits the LH and FSH release induced by LH-RH in immature male rats[1].
[D-Phe2,D-Ala6]-LH-RH (1 mg/rat, SC) shows marked antiovulatory and contraceptive activity[2]. [D-Phe2,D-Ala6]-LH-RH (0.625, 1.25, 2.5 mg/kg; s.c.; single dose; sacrificed 30 minutes) results a dose-dependent increase in stalk-median eminence (SME)-LHRH activity and decreases plasma LHRH activity as well in rats with hypophysectomized (hypox) at 25 days old[3].
[D-Phe2,D-Ala6]-LH-RH (25 mg/kg; s.c.; single dsoe) is effective in blocking the ovulation normally induced by LRH alone[4].

Animal Model:Adult female Sprague-Dawley rats (200-250 g)[2]
Dosage:1 mg/rat
Administration:SC injections, from 12:00 to 14:30 hr on the day of proestrus
Result:Showed marked antiovulatory and contraceptive activity, with 96% inhibition of ovulation.
References[1] Vilchez-Martinez JA, et al. Comparison of the anti-LH/FSH-RH and anti-ovulatory activities of (D-Phe2, D-Leu6)-LH-RH and (D-Phe2, D-Ala6)-LH-RH. Endocr Res Commun. 1976;3(3-4):231-41. DOI:10.3109/07435807609056903
[2] Beattie CW, et al. Luteinizing hormone-releasing hormone. Antiovulatory activity of analogs substituted in positions 2 and 6. J Med Chem. 1975 Dec;18(12):1247-50. DOI:10.1021/jm00246a016
[3] Corbin A, et al. Effect of luteinizing hormone releasing hormone (LHRH) and an LHRH antagonist of hypothalamic and plasma LHRH of hypophysectomized rats. Endocrinology. 1976 Jan;98(1):247-50. DOI:10.1210/endo-98-1-247
[4] Corbin A, et al. Ihibition of the pre-ovulatory proestrous gonadotropin surge, ovulation and pregnancy with a peptide analogue of luteinizing hormone releasing hormone. Endocr Res Commun. 1975;2(1):1-23. DOI:10.3109/07435807509053836
Pglu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 Preparation Products And Raw materials
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