| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
4-Chloro-6-(trifluoromethyl)quinoline manufacturers
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| | 4-Chloro-6-(trifluoromethyl)quinoline Basic information |
| Product Name: | 4-Chloro-6-(trifluoromethyl)quinoline | | Synonyms: | 4-CHLORO-6-(TRIFLUOROMETHYL)QUINOLINE;BUTTPARK 14\01-63;4-Chloro-6-(trifluoromethyl)quinoline 98%;4-Chloro-6-(trifluoromethyl)quinoline98%;4-Chloro-6-(trifluoroMethyl)quinolline;4-Chloro-6-(trifluoromethyl)-1-azanaphthalene;Quinoline, 4-chloro-6-(trifluoromethyl)- | | CAS: | 49713-56-6 | | MF: | C10H5ClF3N | | MW: | 231.6 | | EINECS: | | | Product Categories: | Quinoline&Isoquinoline | | Mol File: | 49713-56-6.mol |  |
| | 4-Chloro-6-(trifluoromethyl)quinoline Chemical Properties |
| Melting point | 48°C | | Boiling point | 265.5±35.0 °C(Predicted) | | density | 1.427±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 2.45±0.16(Predicted) | | Appearance | Pale purple to purple Solid | | InChI | InChI=1S/C10H5ClF3N/c11-8-3-4-15-9-2-1-6(5-7(8)9)10(12,13)14/h1-5H | | InChIKey | FTNQANJWBFKPIP-UHFFFAOYSA-N | | SMILES | N1C2C(=CC(C(F)(F)F)=CC=2)C(Cl)=CC=1 | | CAS DataBase Reference | 49713-56-6(CAS DataBase Reference) |
| Provider | Language |
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ALFA
| English |
| | 4-Chloro-6-(trifluoromethyl)quinoline Usage And Synthesis |
| Synthesis | 4-Hydroxy-6-trifluoromethylquinoline (50 mg, 0.2 mmol) was used as starting material and synthesized with reference to the method reported in Bioorganic & Medicinal Chemistry Letters, 2005, 15(4), 1015-1018. The raw material was added to phosphorus trichloride (108 mg, 0.7 mmol). After the addition was completed, the reaction mixture was heated to 90 °C and stirred continuously for 2 hours. Upon completion of the reaction, the pH was adjusted to 8-9 by slow dropwise addition of saturated sodium bicarbonate solution.Subsequently, extraction was carried out with ethyl acetate (30 mL x 3). The organic phases were combined and concentrated under reduced pressure to afford the target product 4-chloro-6-(trifluoromethyl)quinoline (60 mg, colorless oil), which could be used directly in the subsequent reaction without further purification. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 4, p. 1015 - 1018
[2] Patent: KR2016/6207, 2016, A. Location in patent: Paragraph 0188; 0191-0194
[3] Patent: US2016/108035, 2016, A1. Location in patent: Paragraph 0136-0137 |
| | 4-Chloro-6-(trifluoromethyl)quinoline Preparation Products And Raw materials |
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