壳梭孢(菌)素
| 中文名称 | 壳梭孢(菌)素 |
|---|---|
| 中文同义词 | 壳梭孢菌素 来源于扁桃壳梭菌;壳梭孢(菌)素;FUSICOCCIN,真菌化脓毒素;化合物 FUSICOCCIN;FUSICOCCIN,H+-ATPASE活化剂 |
| 英文名称 | FUSICOCCIN |
| 英文同义词 | FUSICOCCIN;fusicoccin from fusicoccum amygdali;3-[2-(Acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethylcyclopenta[a,d]-dicylo coten-4-yl-6;.alpha.-D-Glucopyranoside, 3-[2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6A,7,8,9,10A-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10A-dimethyldicyclopenta[A,D]cycloocten-4-yl 6-o-(1,1-dimethyl-2-propenyl)-, 3-acetate, [1S-[1.alpha.,3(R*),4.alpha.,5.beta.,6.beta.,6A.alpha.,9.beta.,10A.beta.]]-;Fucicoccin;Fusicoccin a;Nsc113500;Fusicoccin-A (Fusicoccin |
| CAS号 | 20108-30-9 |
| 分子式 | C36H56O12 |
| 分子量 | 680.82 |
| EINECS号 | |
| 相关类别 | Carbohydrates;Carbohydrates A to;Carbohydrates D-FBiochemicals and Reagents;Monosaccharide |
| Mol文件 | 20108-30-9.mol |
| 结构式 |  |
壳梭孢(菌)素 性质
| 储存条件 | −20°C |
|---|---|
| 溶解度 | 可溶于DMSO |
| 形态 | 白色固体。 |
| 颜色 | 白色至米白色 |
| 生物来源 | plant (Fusicoccum amygdali) |
| InChIKey | KXTYBXCEQOANSX-QFEZKATASA-N |
| SMILES | COCC1CCC2C(C)C(O)C(OC3OC(COC(C)(C)C=C)C(O)C(OC(C)=O)C3O)C4=C(CC(O)C4(C)C=C12)C(C)COC(C)=O |
Fusicoccin (Fusicoccin A)，一种真菌化脓毒素，14-3-3 蛋白相互作用的稳定剂。Fusicoccin 使 H+-ATPase/14-3-3 复合物在植物中稳定，保持酶的激活状态。Fusicoccin 还稳定 14-3-3 蛋白与含有 C-末端 14-3-3 识别基序的结合伙伴的相互作用，如 ERα、GPIbα、TASK3、CTFR 和 p53。Fusicoccin 诱导一些癌细胞调亡，并具有抗癌活性。
Fusicoccin (Fusicoccin A) stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth (EC
50
=29 mM).
Fusicoccin A activates the plasma membrane H
+
-ATPase by stabilizing its binding to 14-3-3 proteins, which results in water loss and the wilting of infected plants. Fusicoccin A decreases the proliferation and migration of human GBM cell lines in vitro, including several cell lines that exhibit varying degrees of resistance to pro-apoptotic stimuli. The IC
50
growth inhibitory concentration of fusicoccin A is 92 µM in the U373-MG cells and 83 µM in the Hs683 glioma cells.
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-122815 | 壳梭孢(菌)素 Fusicoccin | 20108-30-9 | 1mg | 9600元 |