N6-Methyladenosine 5'-monophosphate sodium salt

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N6-Methyladenosine 5'-monophosphate sodium salt Basic information
Product Name:N6-Methyladenosine 5'-monophosphate sodium salt
Synonyms:N6-methyladenosine 5'-monophosphate*sodium;N6-Methyladenosine 5'-Monophosphate sodiuM salt ~98% (HPLC);N6-Methyladenosine 5'-monophosphate sodium salt >=97% (HPLC);ML-210N6-Methyladenosine 5'-monophosphate (sodium salt);N-Methyl-5'-adenylic acid disodium salt;6-Me-5'-AMP;N6-Methyladenosine 5'-monophosphate disodium salt;N6-Methyladenosine 5'-monophosphate sodium salt (N6-Methyl-AMP)
CAS:81921-35-9
MF:C11H14N5Na2O7P
MW:405.21
EINECS:
Product Categories:NucleosidesBiochemicals and Reagents;Nucleosides, Nucleotides, Oligonucleotides;Nucleotide Analogs;Oligonucleotide Synthesis;Specialty Synthesis
Mol File:81921-35-9.mol
N6-Methyladenosine 5'-monophosphate sodium salt Structure
N6-Methyladenosine 5'-monophosphate sodium salt Chemical Properties
storage temp. -20°C
solubility PBS (pH 7.2): 10 mg/ml
form A crystalline solid
color White to light brown
InChIKeyHFOKUKRAZPHTHH-LYYWGVPGSA-L
SMILES[Na].CNc1ncnc2n(cnc12)C3OC(COP(O)(O)=O)C(O)C3O
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
N6-Methyladenosine 5'-monophosphate sodium salt Usage And Synthesis
DescriptionN6-Methyladenosine 5''-monophosphate is an activator of glycogen phosphorylase b (Ka = 22 μM). It is also a non-competitive inhibitor of rat adenylate kinase II (Ki = 4.2 mM). N6-Methyladenosine 5’-monophosphate (sodium salt) has been used for immunoprecipitation of N6-methyladenosine.
Chemical PropertiesWhite to off-white free flowing powder
UsesN6-Methyladenosine-5''-monophosphate Sodium Salt is used in method for improving the yield of m6A antibody enriched methylated mRNA.
UsesN6-Methyladenosine 5′-monophosphate sodium salt can be used in N6-methyladenosine (m6A) ribonucleoprotein immunoprecipitation reactions. m6A has gained a lot of attention in the recent years because the mRNA modification with m6A has been shown to play a role in stability and translational efficiency of mRNA.
Biochem/physiol ActionsA glycogen phosphorylase b activator.
References[1] MICHEL MORANGF. AMP Analogs: Their Function in the Activation of Glycogen Phosphorylase b[J]. The FEBS journal, 1976, 65 2: 553-563. DOI: 10.1111/j.1432-1033.1976.tb10373.x
[2] TON T. HAI. Species- or isozyme-specific enzyme inhibitors. 7. Selective effects in inhibitions of rat adenylate kinase isozymes by adenosine 5’-phosphate derivatives[J]. Journal of Medicinal Chemistry, 1982, 25 7: 806-812. DOI: 10.1021/jm00349a008
[3] NATE J FRY. N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs.[J]. RNA, 2017, 23 9: 1444-1455. DOI: 10.1261/rna.061044.117
N6-Methyladenosine 5'-monophosphate sodium salt Preparation Products And Raw materials
Tag:N6-Methyladenosine 5'-monophosphate sodium salt(81921-35-9) Related Product Information
6-Methylaminopurine 9-ribofuranoside (+/-)-Dihydrozeatin riboside 5'-monophosphate disodium salt monohydrate N6-Methyladenosine 5'-monophosphate sodium salt N6-Methyl-2'-deoxy-adenosine Adenosine 5'-monophosphate sodium salt 2'-DEOXYADENOSINE 5'-MONOPHOSPHATE SODIUM SALT ADENOSINE5'-MONOPHOSPHATESODIUMSALT 2'-Deoxyadenosine 5'-phosphate KINETIN RIBOSIDE 5'-MONOPHOSPHATE DISODIUM SALT 5'-PUMP SODIUM SALT SODIUM GLYCEROPHOSPHATE HYDRATE Adenosine 5'-monophosphate monohydrate Sodium phosphate dibasic dodecahydrate