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Alfa Aesar |
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400-6106006 |
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(-)-COTININE manufacturers
- Cotinine
-
- $59.00
-
2026-07-17
- CAS:486-56-6
- Purity: 99.94%
- Supply Ability: 10g
- Cotinine
-
- $59.00
-
2026-07-17
- CAS:486-56-6
- Purity: 99.94%
- Supply Ability: 10g
- (-)-COTININE
-
-
2026-05-18
- CAS:486-56-6
- Min. Order: 1kg
- Purity: 98%
Related articles - Mechanism of COTININE
- Cotinine is the major metabolite of nicotine. In the liver, nicotine is rapidly metabolized to cotinine (70–80%) by CYP2A6 and....
- Jan 12，2022
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| | (-)-COTININE Basic information |
| | (-)-COTININE Chemical Properties |
| Melting point | 40-42 °C(lit.) | | Boiling point | 250 °C150 mm Hg(lit.) | | alpha | [α]D20 -18～-22° (c=1, C2H5OH) | | density | 1.1102 (rough estimate) | | refractive index | 1.7110 (estimate) | | Fp | >230 °F | | storage temp. | Sealed in dry,2-8°C | | solubility | Chloroform (Sparingly), DMSO (Slightly), Methanol (Sparingly) | | form | Solid | | pka | 4.72±0.12(Predicted) | | color | Colourless to Very Dark Orange Oil | | Optical Rotation | [α]/D -21±2°, c = 1 in ethanol | | Water Solubility | Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform. | | Merck | 14,2553 | | BRN | 83099 | | Henry's Law Constant | 3.0×106 mol/(m3Pa) at 25℃, HSDB (2015) | | Stability: | Stable. Incompatible with strong oxidizing agents. May be heat sensitive - store cold. | | InChI | 1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1 | | InChIKey | UIKROCXWUNQSPJ-VIFPVBQESA-N | | SMILES | CN1[C@@H](CCC1=O)c2cccnc2 | | EPA Substance Registry System | Cotinine (486-56-6) |
| | (-)-COTININE Usage And Synthesis |
| Description | Cotinine is the major metabolite of nicotine. In the liver,
nicotine is rapidly metabolized to cotinine (70–80%) by
CYP2A6 and to nornicotine (5%) by CYP2A6 and CYP2B6.
With a half-life about 10-fold longer than that of nicotine
(15–19 h for cotinine versus 2–3 h for nicotine), cotinine
induces plasma concentrations of 1–3 mM in smokers. After
administration to rats, cotinine levels in the brain reach
fourfold those of nicotine at 4 h following injection. Cotinine
is not biotransformed in the brain, allowing accumulation
of this substance to levels greater than that of
nicotine.
Like nicotine, cotinine is able to induce dopamine release in
smokers and in superfused rat striatal slices in a dose- and
calcium-dependent manner via the nicotinic receptors, but
only at concentrations higher than those normally seen in
smokers. Indeed, administration of cotinine to smokers at
levels 10-fold that is seen following smoking had no observable
effect, suggesting that cotinine is not neuroactive at doses
found in smokers. However, cotinine also acts as an inhibitor
for nicotine binding in rat brain via desensitization of the
nicotinic receptor. | | Chemical Properties | Colourless to Light Brown Solid | | Uses | A major metabolite of nicotine in humans | | Uses | A major metabolite of Nicotine (N412450) in humans. Carcinogen. | | Uses | antidepressant | | Uses | (-)-Cotinine is used to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task. | | Definition | ChEBI: An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum. | | Synthesis Reference(s) | Synthetic Communications, 18, p. 1331, 1988 DOI: 10.1080/00397918808078800 | | Biological Activity | Major metabolite of nicotine. Shown to activate a subpopulation of α 3/ α 6 β 2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo . | | Environmental Fate | Cotinine stimulates dopamine release in the nigrostriatal
pathway by activating nicotinic acetylcholine receptors.
However, its lower EC50 prevents significant activation of this
pathway in smokers. | | Toxicity evaluation | Cotinine has a vapor pressure of 3.8×10-4mmHg at 25 °C.
Cotinine will be photochemically degraded with a half-life of
15 h. In sediment, cotinine is completely degraded to carbon
dioxide within 72 h. It is not expected to bioaccumulate in
aquatic organisms. |
| | (-)-COTININE Preparation Products And Raw materials |
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