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| | 3-Amino-3-(2-fluoro-phenyl)-propionic acid Basic information |
| Product Name: | 3-Amino-3-(2-fluoro-phenyl)-propionic acid | | Synonyms: | RARECHEM AK HC T305;3-amino-3-(2-fluorophenyl)propanoic acid(SALTDATA: FREE);3-Amino-3-(2-fluorophenyl)propanoicacid95%;(RS)-3-Amino-3-(2-fluorophenyl)-propionic acid;DL-3-Amino-3-(2-fluorophenyl)propanoic acid;3-AMINO-3-(2-FLUOROPHENYL)PROPANOIC ACID;DL-3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID;β-amino-β-(2-fluorophenyl)propionic acid | | CAS: | 117391-49-8 | | MF: | C9H10FNO2 | | MW: | 183.18 | | EINECS: | 604-604-1 | | Product Categories: | B-Amino | | Mol File: | 117391-49-8.mol |  |
| | 3-Amino-3-(2-fluoro-phenyl)-propionic acid Chemical Properties |
| Melting point | 222-224 | | Boiling point | 302.6±32.0 °C(Predicted) | | density | 1.289±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 3.67±0.10(Predicted) | | Appearance | White to off-white Solid |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2922390090 |
| | 3-Amino-3-(2-fluoro-phenyl)-propionic acid Usage And Synthesis |
| Synthesis | GENERAL METHOD: Malonic acid (1.04 g, 10 mmol) and ammonium formate (1.26 g, 20 mmol) were dissolved in ethanol (50 mL), followed by the addition of 2-fluorobenzaldehyde (10 mmol). The reaction mixture was heated to reflux for 7 hours. After completion of the reaction, it was cooled to room temperature and the crude product was collected by filtration. The crude product was purified by recrystallization (using 95% ethanol as a solvent) to give 3-amino-3-(2-fluorophenyl)propionic acid as a final white solid. | | References | [1] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 402 - 418
[2] Advanced Synthesis and Catalysis, 2010, vol. 352, # 2-3, p. 395 - 406
[3] Advanced Synthesis and Catalysis, 2017, vol. 359, # 9, p. 1570 - 1576
[4] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 11, p. 1207 - 1212
[5] Journal of Organic Chemistry, 2009, vol. 74, # 23, p. 9152 - 9157 |
| | 3-Amino-3-(2-fluoro-phenyl)-propionic acid Preparation Products And Raw materials |
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