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| | MN(III) PROTOPORPHYRIN IX CHLORIDE Basic information |
| Product Name: | MN(III) PROTOPORPHYRIN IX CHLORIDE | | Synonyms: | MN(III) PROTOPORPHYRIN IX CHLORIDE;8,13-BIS(VINYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID MANGANESE(III) CHLORIDE;BJLYQWVPQKTSMI-UHFFFAOYSA-K;Manganate(2-),chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13)-;Mn(Ⅲ) Protoporphyrin IX Chloride | | CAS: | 120389-54-0 | | MF: | C34H32ClMnN4O4 | | MW: | 651.03 | | EINECS: | | | Product Categories: | Porphyrins | | Mol File: | Mol File |  |
| | MN(III) PROTOPORPHYRIN IX CHLORIDE Chemical Properties |
| solubility | 0.1 M Na2CO3: 5 mg/ml2 M NaOH: 10 mg/ml |
| | MN(III) PROTOPORPHYRIN IX CHLORIDE Usage And Synthesis |
| Uses | Mn(III) protoporphyrin IX chloride is a metalloporphyrin. It induces mRNA expression of the genes encoding δ-aminolevulinate synthase and heme oxygenase (HO), enzymes that catalyze the rate-limiting steps of heme biosynthesis and degradation, respectively, in chick embryo liver cells when used at a concentration of 10 μM. Mn(III) protoporphyrin IX chloride-containing nanobialys have been used in magnetic resonance imaging (MRI) of fibrin clots in vitro. It has also been used in the synthesis of Mn(III) protoporphyrin IX-6(7)-glycyl-glycyl-L-histidine methyl ester (MnGGH), a metalloporphyrin conjugate with microperoxidase activity. | | References | [1] Cable, et al. Differential effects of metalloporphyrins on messenger RNA levels of δ-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells. J. Clin. Invest. 94(2), 649-654 (1994).
[2] DIPANJAN PAN. Ligand-Directed Nanobialys as Theranostic Agent for Drug Delivery and Manganese-Based Magnetic Resonance Imaging of Vascular Targets[J]. Journal of the American Chemical Society, 2008, 130 29: 9186-9187. DOI: 10.1021/ja801482d
[3] RYABOVA E S, NORDLANDER E. Synthesis and reactivity studies of a manganese ‘microperoxidase’ containing b-type heme†[J]. Dalton Transactions, 2005, 7. DOI: 10.1039/b417331g |
| | MN(III) PROTOPORPHYRIN IX CHLORIDE Preparation Products And Raw materials |
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